SAMD8 transforms PE and CERA to CPE

Stable Identifier
R-HSA-8959462
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Sphingolipids such as sphingomyelin (SM) are important components of cellular membranes and dynamic regulators of a wide range of cellular processes in most organisms. Ceramides constitute the backbone of all sphingolipids and are synthesised on the cytosolic surface of the endoplasmic reticulum (ER) then transported to the Golgi for conversion to SM. The ER-membrane resident protein sphingomyelin synthase-related protein 1 (SAMD8) catalyses the synthesis of the SM analogue ceramide phosphoethanolamine (CPE) in the ER lumen. SAMD8 only produces trace amounts of CPE but blocking its catalytic activity causes a substantial rise in ER ceramide levels and a structural collapse of the early secretory pathway. SAMD8 is therefore a key regulator of ceramide homeostasis, functioning as a sensor rather than a converter of ceramides in the ER (Vacaru et al. 2009).

Literature References
PubMed ID Title Journal Year
19506037 Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER

Vacaru, AM, Tafesse, FG, Ternes, P, Kondylis, V, Hermansson, M, Brouwers, JF, Somerharju, P, Rabouille, C, Holthuis, JC

J. Cell Biol. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ceramide phosphoethanolamine synthase activity of SAMD8 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Created