Phosphorylated FUNDC1 links damaged mitochondria to LC3

Stable Identifier
R-HSA-8959573
Type
Reaction [binding]
Species
Homo sapiens
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s17 Phosphorylated FUNDC1 links to the microtubule-associated protein Autophagy marker Light Chain 3 (LC3). This begins the recruitment of the autophagy machinery to the damaged mitochondria, targeting it for autophagic degradation.

Literature References
PubMed ID Title Journal Year
22267086 Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

Liu, L, Feng, D, Chen, G, Chen, M, Zheng, Q, Song, P, Ma, Q, Zhu, C, Wang, R, Qi, W, Huang, L, Xue, P, Li, B, Wang, X, Jin, H, Wang, J, Yang, F, Liu, P, Zhu, Y, Sui, S, Chen, Q

Nat. Cell Biol. 2012
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