RLBP1:11cRAL dissociates

Stable Identifier
R-HSA-8960973
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Interphotoreceptor retinoid-binding protein (RBP3) is the major soluble protein in the interphotoreceptor matrix (IPM) (Liou et al. 1989, Fong & Bridges 1988). It is thought to shuttle 11-cis-retinal (11cRAL) between retinal pigment epithelium (RPE) and photoreceptor outer segments during the visual cycle but the mechanism is poorly understood (Gonzalez-Fernandez & Ghosh 2008). It is assumed cellular retinaldehyde-binding protein (RLBP1) must dissociate from 11cRAL before 11cRAL is transported as RLBP1 is not present in photoreceptor cells.

Literature References
PubMed ID Title Journal Year
2542268 Human interstitial retinoid-binding protein. Gene structure and primary structure

Liou, GI, Ma, DP, Yang, YW, Geng, L, Zhu, C, Baehr, W

J. Biol. Chem. 1989
3170584 Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA

Fong, SL, Bridges, CD

J. Biol. Chem. 1988
Participants
Participant Of
Orthologous Events
Authored
Reviewed