RLBP1:11cRAL dissociates

Stable Identifier
R-HSA-8960973
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Interphotoreceptor retinoid-binding protein (RBP3) is the major soluble protein in the interphotoreceptor matrix (IPM) (Liou et al. 1989, Fong & Bridges 1988). It is thought to shuttle 11-cis-retinal (11cRAL) between retinal pigment epithelium (RPE) and photoreceptor outer segments during the visual cycle but the mechanism is poorly understood (Gonzalez-Fernandez & Ghosh 2008). It is assumed cellular retinaldehyde-binding protein (RLBP1) must dissociate from 11cRAL before 11cRAL is transported as RLBP1 is not present in photoreceptor cells.
Literature References
PubMed ID Title Journal Year
3170584 Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA

Bridges, CD, Fong, SL

J. Biol. Chem. 1988
2542268 Human interstitial retinoid-binding protein. Gene structure and primary structure

Geng, L, Zhu, C, Liou, GI, Ma, DP, Baehr, W, Yang, YW

J. Biol. Chem. 1989
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