CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex

Stable Identifier
R-HSA-8961619
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
E2F1 directly stimulates transcription of the CDC6 gene (Yan et al., 1998; Ohtani et al., 1998). CDC6 is required to recruit the MCM2-7 replication helicases.
Transcription of the CDC6 gene is directly repressed by the DREAM complex (Litovchick et al. 2007).
Literature References
PubMed ID Title Journal Year
9778043 Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F.

Ohtani, K, Ikeda, M, Nakamura, M, Tsujimoto, A

Oncogene 1998
9520412 Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.

Leone, G, Williams, RS, Nevins, JR, DeGregori, J, Stillman, B, Shohet, R, Yan, Z

Proc Natl Acad Sci U S A 1998
17531812 Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence

DeCaprio, JA, Washburn, MP, Swanson, SK, Zhu, X, Florens, LA, Chen, R, Litovchick, L, Liu, XS, Sadasivam, S, Velmurugan, S

Mol Cell 2007
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
DREAM complex:CDC6 gene [nucleoplasm] (Homo sapiens)
Active Unit
DREAM complex [nucleoplasm]
Positively by
Regulator
E2F1:TFDP1,TFDP2:CDC6 gene [nucleoplasm] (Homo sapiens)
Active Unit
E2F1:TFDP1,TFDP2 [nucleoplasm]
Authored
Gopinathrao, G  (2004-06-16)
Reviewed
MacPherson, D  (2011-08-25)
Bosco, G  (2004-06-16)
Created
Orlic-Milacic, M  (2017-02-03)
Cite Us!