E2F1 binds the CDC6 gene promoter

Stable Identifier
R-HSA-8961620
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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E2F1 binds the CDC6 gene promoter
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E2F1 binds to E2F binding sites in the promoter of the CDC6 gene (Yan et al., 1998; Ohtani et al., 1998). CDC6 is required to recruit the MCM2-7 replication helicases.
Literature References
PubMed ID Title Journal Year
9778043 Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F.

Ohtani, K, Ikeda, M, Nakamura, M, Tsujimoto, A

Oncogene 1998
9520412 Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.

Leone, G, Williams, RS, Nevins, JR, DeGregori, J, Stillman, B, Shohet, R, Yan, Z

Proc Natl Acad Sci U S A 1998
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Authored
Gopinathrao, G  (2004-06-16)
Reviewed
Bosco, G  (2004-06-16)
Created
Orlic-Milacic, M  (2017-02-03)
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