PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex

Stable Identifier
R-HSA-8961665
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
E2F1 directly stimulates transcription of the PCNA gene, which encodes the proliferating cell nuclear antigen, a component of the DNA polymerase complex involved in eukaryotic DNA replication (DeGregori et al. 1995, Li et al. 2003).
The PCNA gene transcription is directly repressed by the DREAM complex (Litovchick et al. 2007).
Literature References
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
DREAM complex:PCNA gene [nucleoplasm] (Homo sapiens)
Active Unit
DREAM complex [nucleoplasm]
Positively by
Regulator
E2F1:TFDP1,TFDP2:PCNA gene [nucleoplasm] (Homo sapiens)
Active Unit
E2F1:TFDP1,TFDP2 [nucleoplasm]
Authored
Gopinathrao, G  (2004-06-16)
Reviewed
Bosco, G  (2004-06-16)
MacPherson, D  (2011-08-25)
Created
Orlic-Milacic, M  (2017-02-04)
Cite Us!