IL9 binds IL9R:JAK1 and IL2RG:JAK3

Stable Identifier
R-HSA-8963734
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Interleukin-9 (IL9) binds to the Interleukin-9 receptor (IL9R) and Cytokine common gamma chain subunit (IL2RG) forming a ligand-receptor complex (Kimura et al 1995, Nizsalóczki et al. 2014). IL2RG is essential for IL9 dependent growth signal transduction (Kimura et al. 1995). IL9R (glycoprotein of 64 kDa) has saturable and specific binding sites with a Kd of 100 pM (Renauld et al. 1992). IL9R colocalize with Interleukin-2 receptors and MHC molecules in lipid rafts of human T lymphoma cells so it is suggested that interactions within these membrane clusters could affect the assembly and signaling capability of the receptors (Nizsalóczki et al. 2014). Moreover, there is evidence that Tyrosine protein kinase JAK1 (JAK1) cooperates with Tyrosine protein kinase JAK3 (JAK3) in signaling through IL2RG-containing receptors (Haan et al. 2011).

Literature References
PubMed ID Title Journal Year
21439476 Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors

Haan, C, Rolvering, C, Raulf, F, Kapp, M, Drückes, P, Thoma, G, Behrmann, I, Zerwes, HG

Chem. Biol. 2011
25297818 Distinct spatial relationship of the interleukin-9 receptor with interleukin-2 receptor and major histocompatibility complex glycoproteins in human T lymphoma cells

Nizsalóczki, E, Csomós, I, Nagy, P, Fazekas, Z, Goldman, CK, Waldmann, TA, Damjanovich, S, Vámosi, G, Mátyus, L, Bodnár, A

Chemphyschem 2014
7718508 Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex

Kimura, Y, Takeshita, T, Kondo, M, Ishii, N, Nakamura, M, Van Snick, J, Sugamura, K

Int Immunol 1995
1376929 Expression cloning of the murine and human interleukin 9 receptor cDNAs

Renauld, JC, Druez, C, Kermouni, A, Houssiau, F, Uyttenhove, C, Van Roost, E, Van Snick, J

Proc Natl Acad Sci U S A 1992
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!