Reactome | 1,25(OH)2D binds VDR

1,25(OH)2D binds VDR

Stable Identifier

R-HSA-8963915

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The biologically active form of vitamin D, 1-alpha, 25-dihydroxyvitamin D (1,25(OH)2D), interacts with the nuclear hormone receptor vitamin D receptor (VDR) in the nucleoplasm of any target tissue (Neme et al. 2017). VDR regulates the actions of 1,25(OH)2D and their binding recruits coactivators (Eelen et al. 2005, Kim et al. 2005, Du et al. 2017) to initiate a signaling response that regulates an estimated upwards of 2000 genes involved in calcium homeostasis, immune responses, cellular growth, differentiation and apoptosis (Hossein-nezhad et al. 2013, Hossein-nezhad & Holick 2013, Wolden-Kirk et al. 2012, Prietl et al. 2013, Hewison 2012, Christakos et al. 2016, Bandera Merchan et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
21849106	Vitamin D and immune function: an overview Hewison, M	Proc Nutr Soc	2012
15728261	Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction Eelen, G, Verlinden, L, Rochel, N, Claessens, F, De Clercq, P, Vandewalle, M, Tocchini-Valentini, G, Moras, D, Bouillon, R, Verstuyf, A	Mol. Pharmacol.	2005
23857223	Vitamin D and immune function Prietl, B, Treiber, G, Pieber, TR, Amrein, K	Nutrients	2013
28206978	Pathogenic roles of alterations in vitamin D and vitamin D receptor in gastric tumorigenesis Du, C, Yang, S, Zhao, X, Dong, H	Oncotarget	2017
22877430	Extraskeletal effects of vitamin D Wolden-Kirk, H, Gysemans, C, Verstuyf, A, Mathieu, C	Endocrinol. Metab. Clin. North Am.	2012
27913313	The role of vitamin D and VDR in carcinogenesis: Through epidemiology and basic sciences Bandera Merchan, B, Morcillo, S, Martin-Nuñez, G, Tinahones, FJ, Macías-González, M	J. Steroid Biochem. Mol. Biol.	2017
15647825	1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts Kim, S, Shevde, NK, Pike, JW	J. Bone Miner. Res.	2005