HDL clearance

Stable Identifier
R-HSA-8964011
Type
Pathway
Species
Homo sapiens
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Clearance of circulating HDL particles involves particle binding to cell-surface SR-BI receptors, particle disassembly with rlease of pre-beta HDL (Silver & Tall 2001), and uptake of the latter mediated by cell-surface CUBN:AMN complex (Kozyraki et al. 1999).

Literature References
PubMed ID Title Journal Year
11561168 The cellular biology of scavenger receptor class B type I

Silver, DL, Tall, AR

Curr Opin Lipidol 2001
10371504 The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein

Kozyraki, R, Fyfe, JC, Kristiansen, M, Gerdes, C, Jacobsen, C, Cui, S, Christensen, EI, Aminoff, M, de la Chapelle, A, Krahe, R, Verroust, PJ, Moestrup, SK

Nat Med 1999
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Orthologous Events
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