G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC

Stable Identifier
R-HSA-8964242
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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G-Protein Coupled Receptors sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the alpha subunit of the G protein (GNAI) can directly bind to SRC. In the presence of active GNAI, SRC can autophosphorylate the 416-tyrosine residue, which leads to the subsequent activation of SRC. Physiologically, the SRC family have implications in cell growth and cancer.

Literature References
PubMed ID Title Journal Year
11007482 Src tyrosine kinase is a novel direct effector of G proteins

Ma, YC, Huang, J, Ali, S, Lowry, W, Huang, XY

Cell 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of G alpha (i):GTP:SRC-1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created