BTK in G alpha (12)-BTK complex is activated

Stable Identifier
Reaction [transition]
Homo sapiens
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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein subunit alpha-12 (GNA12) can bind the non-receptor Tyrosine-protein kinase BTK. In this complex, GNA12 triggers BTK activation. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.

Literature References
PubMed ID Title Journal Year
11742120 Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization

Laederach, A, Cradic, KW, Brazin, KN, Zamoon, J, Fulton, DB, Huang, XY, Andreotti, AH

Protein Sci. 2002
9796816 The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain

Jiang, Y, Ma, W, Wan, Y, Kozasa, T, Hattori, S, Huang, XY

Nature 1998
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Orthologous Events
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