G alpha (12) binds BTK

Stable Identifier
R-HSA-8964274
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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G alpha (12) binds BTK
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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein subunit alpha-12 (GNA12) can bind directly to the PH domain of the non-receptor Tyrosine-protein kinase BTK (BTK) in vitro and in vivo. This binding results in the activation of BTK. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.
Literature References
PubMed ID Title Journal Year
9796816 The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain

Kozasa, T, Ma, W, Huang, XY, Wan, Y, Jiang, Y, Hattori, S

Nature 1998
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Orthologous Events
G alpha (12) binds BTK (Bos taurus)
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G alpha (12) binds BTK (Mus musculus)
G alpha (12) binds BTK (Rattus norvegicus)
G alpha (12) binds BTK (Sus scrofa)
Authored
Varusai, TM  (2017-07-27)
Reviewed
Huang, X  (2018-09-13)
Created
Varusai, TM  (2017-02-16)
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