G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein G(q) subunit alpha class (GNAQ/GNA11/GNA14/GNA15) can bind directly to the THSH3 domain of the non-receptor Tyrosine-protein kinase BTK in vitro and in vivo. This binding results in a conformational change in BTK, which leads to its activation. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.
Bence, K, Ma, W, Kozasa, T, Huang, XY
Ma, YC, Huang, XY
Laederach, A, Cradic, KW, Brazin, KN, Zamoon, J, Fulton, DB, Huang, XY, Andreotti, AH
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