G beta:gamma signalling through BTK

Stable Identifier
R-HSA-8964315
Type
Pathway
Species
Homo sapiens
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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G-proteins) that have alpha, beta and gamma subunits. Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. G-protein beta-gamma complex, along with phosphatidylinositol 3,4,5-trisphosphate (PIP3), recruits the non-receptor Tyrosine-protein kinase BTK to the cell membrane. Here, the G-protein beta-gamma complex activates BTK. Subsequently, active BTK dissociates from the complex to phosphorylate downstream substrates. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.

Literature References
PubMed ID Title Journal Year
7567982 Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits

Langhans-Rajasekaran, SA, Wan, Y, Huang, XY

Proc. Natl. Acad. Sci. U.S.A. 1995
11698416 G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase

Lowry, WE, Huang, XY

J. Biol. Chem. 2002
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