PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex

Stable Identifier
R-HSA-8964317
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G-proteins) that have alpha, beta and gamma subunits. Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. G-protein beta-gamma complex, along with phosphatidylinositol 3,4,5-trisphosphate (PIP3), recruits the non-receptor Tyrosine-protein kinase BTK to the cell membrane. Here, the G-protein beta-gamma complex activates BTK. Once active, BTK dissociates from PIP3 and G-protein beta-gamma complex and is released to the cytoplasm to phosphorylate downstream substrates. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.
Literature References
PubMed ID Title Journal Year
11698416 G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase

Huang, XY, Lowry, WE

J. Biol. Chem. 2002
7567982 Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits

Huang, XY, Wan, Y, Langhans-Rajasekaran, SA

Proc. Natl. Acad. Sci. U.S.A. 1995
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