G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12)

Stable Identifier
R-HSA-8964333
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12)
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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein subunit alpha-12 (GNA12) can bind to the non-receptor Tyrosine-protein kinase BTK. This complex facilitates BTK activation. Subsequently, the active BTK dissociates from GNA12 to phosphorylate downstream effectors. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.

Literature References
PubMed ID Title Journal Year
9796816 The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain

Jiang, Y, Ma, W, Wan, Y, Kozasa, T, Hattori, S, Huang, XY

Nature 1998
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Orthologous Events
G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Canis familiaris)
G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Danio rerio)
G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Mus musculus)
G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Rattus norvegicus)
G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Sus scrofa)
Authored
Varusai, TM  (2017-07-27)
Reviewed
Huang, X  (2018-09-13)
Created
Varusai, TM  (2017-02-16)
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