Reactome | CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated

CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated

Stable Identifier

R-HSA-8964604

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated

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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G-proteins) that have alpha, beta and gamma subunits. Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. Serine/threonine-protein kinase PAK 1 binds with Rho guanine nucleotide exchange factor 6 (ARHGEF6, PIX-Alpha) in the cytosol and is subsequently translocated by the G-protein beta-gamma complex to the plasma membrane. Here, the GTPase Cell division control protein 42 homolog (CDC42) binds with this complex. Subsequently, ARHGEF6 acts as a GEF for CDC42 and facilitates the activation of CDC42. CDC42 is known to be involved in epithelial cell polarization processes.

Literature References

PubMed ID	Title	Journal	Year
12887923	Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42 Wu, Y, Li, Z, Mo, Z, Smrcka, AV, Huang, CK, Liu, B, Lu, W, Wu, G, Wu, D, Li, L, Liu, M, Hannigan, M	Cell	2003