Phosphorylated ETS2 binds p16INK4A promoter

Stable Identifier
R-HSA-8979082
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylated ETS2 binds p16INK4A promoter
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ETS2, activated by RAS/RAF/MAP kinase cascade, binds the promoter of p16INK4A in the CDKN2A locus (Ohtani et al. 2001). CDKN2A locus also encodes p14ARF (p19ARF in mouse), but from a different promoter and in a different reading frame. While p16INK4A and p14ARF use different exon 1, (exon 1-alpha and exon 1-beta, respectively), they share exons 2 and 3. However, because the reading frames are different, there is no amino acid sequence similarity between the two proteins (Quelle et al. 1995).
Literature References
PubMed ID Title Journal Year
11234019 Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

Sharrocks, AD, Peters, G, Ohashi, Y, Sugimoto, M, Zebedee, Z, Ohtani, N, Huot, TJ, Hara, E, Stinson, JA

Nature 2001
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
p-T72-ETS2:ID1 [nucleoplasm] (Homo sapiens)
Active Unit
ID1 [nucleoplasm]
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2017-02-21)
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