IL12 bound to IL12R internalises

Stable Identifier
R-HSA-8981093
Type
Reaction [omitted]
Species
Homo sapiens
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Association kinetics based on competition experiments with Iodine125-labeled Interleukin-12 (IL12) in human PHA-activated lymphoblasts suggested that upon binding of IL12 to the IL-12 receptor the IL12 and probably its receptor are subsequently internalized (Chizzonite et al. 1992). Using confocal laser microscopy in human B cells and primary T cells it was shown that after binding of IL12 to the IL-12 receptor heterodimer IL12:IL12RB1:IL12RB2 is indeed internalised into the cell (Durali et al. 2003). This is a black box event because the mechanism is uncertain.

Literature References
PubMed ID Title Journal Year
7911493 Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130

Chua, AO, Chizzonite, R, Desai, BB, Truitt, TP, Nunes, P, Minetti, LJ, Warrier, RR, Presky, DH, Levine, JF, Gately, MK

J. Immunol. 1994
1578138 IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts

Chizzonite, R, Truitt, T, Desai, BB, Nunes, P, Podlaski, FJ, Stern, AS, Gately, MK

J. Immunol. 1992
12893768 In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment

Durali, D, de Goër de Herve, MG, Giron-Michel, J, Azzarone, B, Delfraissy, JF, Taoufik, Y

Blood 2003
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