Nephrin dimer:KIRREL binds FYN

Stable Identifier
R-HSA-8981534
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Nephrin (NPHS1) is tyrosine phosphorylated by the Src family tyrosine kinase FYN in developing and injured podocytes. Phosphorylation of three tyrosines (1176, 1193 and 1217) results in the formation of a preferred binding motif (YDXV) for the SH2 domain of the adaptor protein NCK, which links Nephrin to the cytoskeleton. Phosphorylation of NPHS1 tyrosine 1158 results in a binding motif for the p85 regulatory subunit of PI3K.

Literature References
PubMed ID Title Journal Year
12668668 Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin

Verma, R, Wharram, B, Kovari, I, Kunkel, R, Nihalani, D, Wary, KK, Wiggins, RC, Killen, P, Holzman, LB

J Biol Chem 2003
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