IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3

Stable Identifier
R-HSA-8982163
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
STAT3 is phosphorylated by IL19:IL20RA:p-JAK1:IL20RB:STAT3 activated receptor complex, STAT3 is phosphorylated by IL19/IL19 receptor activated complex
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Signal transducer and activator of transcription 3 (STAT3) is phosphorylated after Interleukin-19 (IL19) binds its receptor complex (Dumoutier et al. 2001, Tian et al. 2008, Jain et al.2011). The receptor complex consists of IL19, Interleukin-20 receptor subunit alpha (IL20RA), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-20 receptor beta (IL20RB) and STAT3.

Literature References
PubMed ID Title Journal Year
11564763 Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types

Dumoutier, L, Leemans, C, Lejeune, D, Kotenko, SV, Renauld, JC

J Immunol 2001
18669613 Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia

Tian, Y, Sommerville, LJ, Cuneo, A, Kelemen, SE, Autieri, MV

Am. J. Pathol. 2008
20966397 The anti-inflammatory cytokine interleukin 19 is expressed by and angiogenic for human endothelial cells

Jain, S, Gabunia, K, Kelemen, SE, Panetti, TS, Autieri, MV

Arterioscler. Thromb. Vasc. Biol. 2011
Participants
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Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL19:IL20RA:p-JAK1:IL20RB:STAT3 [plasma membrane]
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Activity
Orthologous Events
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