Reactome | p-STAT3 [cytosol]

p-STAT3 [cytosol]

Stable Identifier

R-HSA-8982823

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Icon

Locations in the PathwayBrowser for interactor UniProt:Q8TAE8 GADD45GIP1

Expand all

External Reference Information

External Reference

UniProt:P40763 STAT3

Gene Names

STAT3, APRF

Chain

initiator methionine:1, chain:2-770

Reference Genes

BioGPS Gene:6774 STAT3

COSMIC (genes):STAT3 STAT3

CTD Gene:6774 STAT3

dbSNP Gene:6774 STAT3

ENSEMBL:ENSG00000168610 STAT3

HGNC:11364 STAT3

KEGG Gene (Homo sapiens):6774 STAT3

Monarch:6774 STAT3

NCBI Gene:6774 STAT3

OMIM:102582 STAT3

UCSC:P40763 STAT3

Reference Transcript

Other Identifiers

0004120114

0006620273

11720755_at

11720756_at

11750674_a_at

16845126

208991_at

208992_s_at

225289_at

289_at

3757837

3757839

3757841

3757842

3757844

3757845

3757846

3757848

3757854

3757856

3757858

3757860

3757861

3757862

3757864

3757865

3757867

3757868

3757870

3757871

3757873

3757874

3757875

3757881

3757883

3757885

3757888

3757889

3757905

3757906

39708_at

63330_at

8015607

A_23_P100795

A_23_P107206

A_24_P116805

GE61038

GE61402

GO:0000003

GO:0000122

GO:0000228

GO:0000790

GO:0000978

GO:0000981

GO:0001103

GO:0001228

GO:0001659

GO:0001754

GO:0002376

GO:0003674

GO:0003677

GO:0003700

GO:0004879

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005739

GO:0005743

GO:0005829

GO:0005886

GO:0005975

GO:0006091

GO:0006355

GO:0006357

GO:0006366

GO:0006412

GO:0006464

GO:0006606

GO:0006810

GO:0006913

GO:0006914

GO:0006950

GO:0006952

GO:0006953

GO:0006954

GO:0007005

GO:0007049

GO:0007165

GO:0007259

GO:0007267

GO:0007399

GO:0007568

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008285

GO:0009056

GO:0009058

GO:0010033

GO:0010507

GO:0010628

GO:0010730

GO:0014069

GO:0014070

GO:0015031

GO:0016032

GO:0016310

GO:0019221

GO:0019827

GO:0019899

GO:0019901

GO:0019903

GO:0019953

GO:0030154

GO:0030335

GO:0030522

GO:0031490

GO:0031730

GO:0032355

GO:0032870

GO:0032991

GO:0033210

GO:0034097

GO:0034641

GO:0035019

GO:0035259

GO:0035278

GO:0035723

GO:0038111

GO:0038113

GO:0038114

GO:0038155

GO:0040007

GO:0040011

GO:0040014

GO:0042127

GO:0042493

GO:0042531

GO:0042592

GO:0042593

GO:0042755

GO:0042789

GO:0042802

GO:0042803

GO:0043226

GO:0043434

GO:0043565

GO:0044212

GO:0044281

GO:0044320

GO:0044321

GO:0044403

GO:0044798

GO:0045410

GO:0045471

GO:0045648

GO:0045747

GO:0045766

GO:0045820

GO:0045893

GO:0045944

GO:0046902

GO:0046983

GO:0048646

GO:0048708

GO:0048856

GO:0048870

GO:0050804

GO:0051092

GO:0051186

GO:0051726

GO:0060019

GO:0060259

GO:0060396

GO:0060397

GO:0060548

GO:0061024

GO:0070102

GO:0070106

GO:0070757

GO:0071345

GO:0071407

GO:0072540

GO:0090575

GO:0097009

GO:0098685

GO:0098978

GO:0099527

GO:1901215

GO:1902728

GO:1902895

GO:1904685

GO:1905564

GO:2000637

GO:2000737

GO:2001171

GO:2001223

Hs.288544.0.S1_3p_at

ILMN_1663618

ILMN_2401978

ILMN_2410986

L29277_at

PH_hs_0019532

PH_hs_0025138

TC17001531.hg

TC17002638.hg

g12653684_3p_a_at

Participant Of

output

hasComponent

input

p-STAT3 dimerizes

hasMember

Other forms of this molecule

Unfolded STAT3 [cytosol]

p-STAT3 [nucleoplasm]

p-Y705-STAT3 [nucleoplasm]

p-S727-STAT3 [cytosol]

p-Y705,S727-STAT3 [cytosol]

p-Y705-STAT3 [cytosol]

STAT3 [cytosol]

p-Y705-STAT3 [nucleoplasm]

Inferred To

phospho-dstD [cytosol] (Dictyostelium discoideum)

phospho-sta-2 [cytosol] (Caenorhabditis elegans)

Homologues of p-STAT3 [cytosol] (Caenorhabditis elegans)

Homologues of p-STAT3 [cytosol] (Dictyostelium discoideum)

phospho-sta-1 [cytosol] (Caenorhabditis elegans)

phospho-stat3.1 [cytosol] (Xenopus tropicalis)

phospho-dstB [cytosol] (Dictyostelium discoideum)

phospho-dstC [cytosol] (Dictyostelium discoideum)

phospho-Stat3 [cytosol] (Mus musculus)

phospho-Stat3 [cytosol] (Rattus norvegicus)

phospho-stat3 [cytosol] (Danio rerio)

phospho-p-STAT3 [cytosol] (Sus scrofa)

phospho-Stat92E [cytosol] (Drosophila melanogaster)

phospho-dstA [cytosol] (Dictyostelium discoideum)

phospho-STAT3 [cytosol] (Canis familiaris)

phospho-STAT3 [cytosol] (Gallus gallus)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_998827.1, XP_016880461.1, XP_011523447.1, XP_005257674.2, XP_011523448.1, XP_016880464.1, NP_003141.2, NP_644805.1, XP_005257673.2

ZINC - World Drugs

STAT3_HUMAN

OpenTargets

ENSG00000168610

ZINC - Substances

STAT3_HUMAN

ZINC - Biogenic

STAT3_HUMAN

ZINC target

P40763

PRO

P40763

PDB

6QHD, 5AX3, 5U5S

ZINC - Investigational

STAT3_HUMAN

ZINC - Metabolites

STAT3_HUMAN

HPA

ENSG00000168610-STAT3

GeneCards

P40763

Ensembl

ENST00000264657, ENSG00000168610, ENSP00000384943, ENSP00000467985, ENST00000404395, ENSP00000467000, ENST00000588969, ENST00000585517, ENSP00000264657

ZINC - Predictions - Purchasable

STAT3_HUMAN

Orphanet

16805

Interactors (83)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.924	15
UniProt:P43405 SYK	6	SYK [plasma membrane] (R-HSA-139844) p-Y-SYK [plasma membrane] (R-HSA-429432) p-6Y-SYK [cytosol] (R-HSA-983586) p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268) p-6Y-SYK [cytosol] (R-HSA-1861712)	0.873	10
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.842	8
UniProt:P51813 BMX	3	BMX(243-675) [cytosol] (R-HSA-351875) BMX [cytosol] (R-HSA-351917) BMX(1-242) [cytosol] (R-HSA-351899)	0.83	8
UniProt:P51451 BLK	2	BLK [cytosol] (R-HSA-983580) MyrG2-BLK [plasma membrane] (R-HSA-9606871)	0.83	9
UniProt:P42224 STAT1	7	p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624)	0.813	5
UniProt:P04626 ERBB2	117	ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-6Y-ERBB2 E693K [plasma membrane] (R-HSA-9665871) p-6Y-ERBB2 R677L [plasma membrane] (R-HSA-9665864) p-6Y-ERBB2 Q709L [plasma membrane] (R-HSA-9665865) p-6Y-ERBB2 G660D [plasma membrane] (R-HSA-9665866) p-6Y-ERBB2 G660R [plasma membrane] (R-HSA-9665878) p-6Y-ERBB2 V659K [plasma membrane] (R-HSA-9665863) p-6Y-ERBB2 V659E [plasma membrane] (R-HSA-9665874) ERBB2 R678Q [plasma membrane] (R-HSA-9665756) ERBB2 S653C [plasma membrane] (R-HSA-9665754) ERBB2 R677L [plasma membrane] (R-HSA-9665759) ERBB2 G660R [plasma membrane] (R-HSA-9665768) ERBB2 V659E [plasma membrane] (R-HSA-9665752) ERBB2 G660D [plasma membrane] (R-HSA-9665753) ERBB2 V659K [plasma membrane] (R-HSA-9665769) ERBB2 Q709L [plasma membrane] (R-HSA-9665770) ERBB2 E693K [plasma membrane] (R-HSA-9665761) p-6Y-ERBB2 R678Q [plasma membrane] (R-HSA-9665876) p-6Y-ERBB2 S653C [plasma membrane] (R-HSA-9665875) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) ERBB2 [plasma membrane] (R-HSA-372889) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.775	9
IntAct:EBI-1550784 CDKN1A			0.725	6
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.677	4
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.635	4
UniProt:P30626 SRI	1	SRI [sarcoplasmic reticulum membrane] (R-HSA-5490313)	0.635	3
UniProt:P06401 PGR	3	PGR [cytosol] (R-HSA-8948964) SUMO1-K7,K388,K531-PGR [nucleoplasm] (R-HSA-4341032) PGR [nucleoplasm] (R-HSA-3008952)	0.623	3
UniProt:P18031 PTPN1	1	PTPN1 [cytosol] (R-HSA-210625)	0.623	2
UniProt:P45984-1 MAPK9			0.602	3
UniProt:Q810M5 ZDH19			0.576	4
UniProt:P23458 JAK1	6	JAK1 [endosome] (R-HSA-8983168) p-Y1022,Y1023-JAK1 [cytosol] (R-HSA-9005335) p-JAK1 [cytosol] (R-HSA-8950711) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) JAK1 [cytosol] (R-HSA-451898) p-Y-JAK1 [cytosol] (R-HSA-451921)	0.564	2
UniProt:P07949 RET	2	p-5Y-RET [plasma membrane] (R-HSA-8854162) RET [plasma membrane] (R-HSA-8853797)	0.564	3
UniProt:O43318 MAP3K7	10	MAP3K7 [plasma membrane] (R-HSA-9012677) PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-MAP3K7 [cytosol] (R-HSA-168163) p-T187-MAP3K7 [cytosol] (R-HSA-206014) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.558	4
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.556	3
UniProt:Q9DUM3 Q9DUM3			0.556	4
UniProt:Q96HA1-2 POM121			0.556	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:P12268 IMPDH2	4	IMPDH2 [extracellular region] (R-HSA-6806455) IMPDH2 [secretory granule lumen] (R-HSA-6803323) IMPDH2 [ficolin-1-rich granule lumen] (R-HSA-6803330) IMPDH2 [cytosol] (R-HSA-57350)	0.556	3
UniProt:Q9UER7 DAXX	2	DAXX [nucleoplasm] (R-HSA-3222068) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.556	4
IntAct:EBI-9914958 STAT3			0.527	3
IntAct:EBI-1265559 MYC			0.527	3
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.527	5
UniProt:O75116 ROCK2	2	ROCK2 [cytosol] (R-HSA-419058) Activated ROCK2 [cytosol] (R-HSA-4687775)	0.524	3
UniProt:Q14938-4 NFIX			0.524	3
UniProt:Q14938-3 NFIX			0.524	3
UniProt:Q9Y5S9 RBM8A	2	RBM8A [cytosol] (R-HSA-162462) RBM8A [nucleoplasm] (R-HSA-156659)	0.512	3
UniProt:Q98PK8 Q98PK8			0.512	3
UniProt:Q9BVP2 GNL3	1	GNL3 [nucleoplasm] (R-HSA-8869324)	0.508	2
UniProt:Q9ULD0 OGDHL			0.508	2
UniProt:Q13011 ECH1	2	ECH1(1-328) [cytosol] (R-HSA-9033152) ECH1(1-328) [peroxisomal matrix] (R-HSA-9033140)	0.508	2
UniProt:P07384 CAPN1	4	CAPN1 [ficolin-1-rich granule lumen] (R-HSA-6801284) CAPN1 [plasma membrane] (R-HSA-3828038) CAPN1 [extracellular region] (R-HSA-6806485) CAPN1 [cytosol] (R-HSA-3288367)	0.508	2
UniProt:P30084 ECHS1	1	ECHS1 [mitochondrial matrix] (R-HSA-54125)	0.508	3
UniProt:P46781 RPS9	2	RPS9 [cytosol] (R-HSA-72387) RPS9 [nucleoplasm] (R-HSA-6790663)	0.508	2
UniProt:Q92665 MRPS31	1	MRPS31 [mitochondrial inner membrane] (R-HSA-5368198)	0.508	2
UniProt:Q96G01 BICD1	1	BICD1 [cytosol] (R-HSA-8848104)	0.508	2
UniProt:Q8TE76 MORC4			0.508	2
UniProt:O14874 BCKDK	1	BCKDK [mitochondrial matrix] (R-HSA-5693129)	0.508	2
UniProt:Q06520 SULT2A1	1	SULT2A1 [cytosol] (R-HSA-176559)	0.508	2
UniProt:P22736 NR4A1	2	NR4A1 [nucleoplasm] (R-HSA-199831) p-S351-NR4A1 [nucleoplasm] (R-HSA-199846)	0.508	3
UniProt:P31146 CORO1A	1	CORO1A [cytosol] (R-HSA-9636432)	0.508	2
IntAct:EBI-9825772 C-FOS PROMOTER REGION			0.499	2
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.499	5
IntAct:EBI-10039972 MMP2			0.499	2
UniProt:Q9NWQ8 PAG1	2	p-Y317-PAG1 [plasma membrane] (R-HSA-180494) PAG1 [plasma membrane] (R-HSA-180500)	0.499	7
UniProt:P32119 PRDX2	2	PRDX2 [cytosol] (R-HSA-3341292) p-T89-PRDX2 [cytosol] (R-HSA-8868574)	0.499	4
IntAct:EBI-1108795 NPM			0.499	2
IntAct:EBI-9980755 MIR-155			0.499	2
IntAct:EBI-10952519 STAT			0.499	4
UniProt:P22681 CBL	6	p-Y371-CBL [cytosol] (R-HSA-182940) p-Y-CBL [cytosol] (R-HSA-8875457) p-Y371-CBL [plasma membrane] (R-HSA-182923) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) CBL [cytosol] (R-HSA-112199)	0.488	2
UniProt:Q5VWN6 TASO2			0.488	2
IntAct:EBI-10696506 MPZL1			0.488	2
UniProt:Q92569 PIK3R3	2	K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574) PIK3R3 [cytosol] (R-HSA-205223)	0.488	2
UniProt:Q8NEC7 GSTCD			0.488	2
UniProt:P35219 CAH8			0.488	2
UniProt:Q9Y4J8-9 DTNA			0.488	2
UniProt:P27986-2 PIK3R1			0.488	2
UniProt:Q9Y3P9 RABGAP1	1	RABGAP1 [cytosol] (R-HSA-8854144)	0.488	2
UniProt:Q9NVE4 CCD87			0.488	2
UniProt:Q96DZ7 T4S19			0.488	2
UniProt:Q6P1L5 F117B			0.488	2
UniProt:Q8IZQ1 WDFY3			0.488	2
UniProt:KRTAP10-7 P60409-2			0.488	2
UniProt:Q86WK9 PAQR7			0.488	2
UniProt:Q14847 LASP1			0.488	2
UniProt:Q03181-2 PPARD			0.488	2
UniProt:Q15672 TWIST1	1	TWIST1 [nucleoplasm] (R-HSA-445442)	0.488	2
UniProt:Q7L591-3 DOK3			0.488	2
UniProt:Q3KNS6 ZN829			0.488	2
UniProt:Q9UBX0 HESX1			0.488	2
UniProt:Q6ZVU3 Q6ZVU3			0.488	2
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.488	2
UniProt:Q9Y2X9 ZN281			0.488	2
UniProt:P49137 MAPKAPK2	5	p-T222,S272-MAPKAPK2 [nucleoplasm] (R-HSA-199936) MAPKAPK2 [cytosol] (R-HSA-187743) p-S272,T222,T334-MAPKAPK2 [cytosol] (R-HSA-187760) p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (R-HSA-450268) MAPKAPK2 [nucleoplasm] (R-HSA-450235)	0.488	2
UniProt:O95661 DIRA3			0.463	3
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676) p-S276-RELA [nucleoplasm] (R-HSA-5624468)	0.463	4
UniProt:Q9UBE8 NLK	3	p-T298-NLK [cytosol] (R-HSA-4411398) p-T298-NLK [nucleoplasm] (R-HSA-4411376) NLK [cytosol] (R-HSA-4411330)	0.462	2
UniProt:Q99062 CSF3R	1	CSF3R [plasma membrane] (R-HSA-6787734)	0.462	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.462	3