Reactome | p-JAK3 [cytosol]

p-JAK3 [cytosol]

Stable Identifier

R-HSA-8982856

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Literature References

PubMed ID	Title	Journal	Year
7568001	Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15 Johnston, JA, Bacon, CM, Finbloom, DS, Rees, RC, Kaplan, D, Shibuya, K, Ortaldo, JR, Gupta, S, Chen, YQ, Giri, JD	Proc Natl Acad Sci U S A	1995

External Reference Information

External Reference

UniProt:P52333 JAK3

Gene Names

JAK3

Chain

chain:1-1124

Reference Genes

BioGPS Gene:3718 JAK3

COSMIC (genes):JAK3 JAK3

CTD Gene:3718 JAK3

dbSNP Gene:3718 JAK3

ENSEMBL:ENSG00000105639 JAK3

HGNC:6193 JAK3

KEGG Gene (Homo sapiens):3718 JAK3

Monarch:3718 JAK3

NCBI Gene:3718 JAK3

OMIM:600173 JAK3

UCSC:P52333 JAK3

Reference Transcript

RefSeq:NM_000215.3 JAK3

Other Identifiers

0002760164

04660+2.7.10.2

11727257_a_at

11750098_a_at

11750573_x_at

11752613_a_at

1547_at

16870274

1YVJ

2005_s_at

2006_at

2007_g_at

207187_3p_at

207187_at

211108_s_at

211109_at

227677_at

3718

3854628

3854629

3854630

3854631

3854632

3854633

3854634

3854635

3854636

3854638

3854639

3854640

3854641

3854642

3854643

3854644

3854645

3854646

3854649

3854650

3854651

3854653

3854655

3854656

3854658

3854659

3854661

3854662

3854663

3854664

3854665

3854667

3LXK

3LXL

3PJC

3ZC6

3ZEP

46152_at

4HVD

4HVG

4HVH

4HVI

4I6Q

4QPS

4QT1

4RIO

4V0G

4Z16

5LWM

5LWN

5TOZ

5TTS

5TTU

5TTV

5VO6

5W86

5WFJ

6AAK

6DA4

6DB3

6DB4

6DUD

6GL9

6GLA

6GLB

70314

8035351

A0A024R7M7

A_23_P329112

A_24_P308096

A_24_P59667

AAA19626

AAC50226

AAC50227

AAC50542

AAC50950

AAD22741

AAH28068

AAM44860

AC007201

AF513860

BC028068

CCDS12366

CH471106

EAW84638

EAW84639

EAW84640

ENSG00000105639

ENSP00000391676

ENSP00000432511

ENSP00000436421

ENST00000458235

ENST00000458235.5

ENST00000527670

ENST00000527670.5

ENST00000534444

ENST00000534444.1

EntrezGene:3718

EntrezGene:JAK3

g1039418_3p_at

g4557680_3p_at

GE58907

GO:0000165

GO:0000166

GO:0002250

GO:0002376

GO:0002731

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005768

GO:0005829

GO:0005856

GO:0005886

GO:0006464

GO:0006468

GO:0006950

GO:0007155

GO:0007165

GO:0007167

GO:0007260

GO:0008150

GO:0008219

GO:0008283

GO:0009058

GO:0012505

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019221

GO:0019899

GO:0019903

GO:0030154

GO:0030183

GO:0030218

GO:0031410

GO:0032693

GO:0032695

GO:0035556

GO:0035723

GO:0035771

GO:0038110

GO:0038111

GO:0038113

GO:0038114

GO:0042102

GO:0042592

GO:0043029

GO:0043167

GO:0043226

GO:0045087

GO:0045221

GO:0045626

GO:0046425

GO:0048856

GO:0050868

GO:0060397

GO:0070232

GO:0070244

GO:0070669

GO:0070670

GO:0070672

GO:0071104

HGNC:6193

HPA070314

Hs.58643.0.A1_3p_at

ILMN_1739667

IPR000299

IPR000719

IPR000980

IPR001245

IPR008266

IPR011009

IPR016251

IPR017441

IPR019749

IPR020635

IPR020775

IPR036860

IPR041046

IPR041155

IPR041381

JAK3

JAK3-201

JAK3-204

JAK3-207

LRG_77

LRG_77t1

MIM:600173

MIM:600802

NM_000215

NP_000206

PF07714

PF17887

PF18377

PF18379

PH_hs_0023062

PH_hs_0032182

PR00109

PR01823

PR01826

SM00219

SM00252

SM00295

TC19001280.hg

U09607

U09607_at

U31601

U31602

U57096

U70065

UPI0000071146

UPI000020370C

XM_005259896

XM_011527990

XP_005259953

XP_011526292

Participant Of

hasCandidate

p-Y1007,Y1008-JAK2,p-JAK3 [cytosol]

hasComponent

IL2RG:p-JAK3 [plasma membrane]

Other forms of this molecule

JAK3 [endosome]

p-Y-JAK3 [cytosol]

p-Y904,939-JAK3 [plasma membrane]

JAK3 [cytosol]

Inferred To

phospho-p-JAK3 [cytosol] (Bos taurus)

phospho-p-JAK3 [cytosol] (Canis familiaris)

phospho-p-JAK3 [cytosol] (Danio rerio)

phospho-p-JAK3 [cytosol] (Gallus gallus)

phospho-p-JAK3 [cytosol] (Mus musculus)

phospho-p-JAK3 [cytosol] (Rattus norvegicus)

phospho-p-JAK3 [cytosol] (Sus scrofa)

Homologues of p-JAK3 [cytosol] (Danio rerio)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_000206.2

ZINC - World Drugs

JAK3_HUMAN

OpenTargets

ENSG00000105639

ZINC - FDA approved

JAK3_HUMAN

ZINC - Substances

JAK3_HUMAN

ZINC target

P52333

ZINC - Biogenic

JAK3_HUMAN

PRO

P52333

PDB

6DUD, 6AAK, 5TOZ, 4RIO, 5W86, 5VO6, 4V0G, 6NY4, 5TTV, 3ZEP, 6DA4, 6DB3, 4QT1, 6DB4, 5TTU, 4HVI, 3PJC, 4HVH, 5LWN, 5TTS, 6GL9, 1YVJ, 5LWM, 3LXL, 4I6Q, 3ZC6, 4Z16, 4HVG, 6GLA, 3LXK, 4QPS, 4HVD, 5WFJ, 6GLB

ZINC - Investigational

JAK3_HUMAN

GeneCards

P52333

Orphanet

16280

ZINC - Predictions - Purchasable

JAK3_HUMAN

HMDB Protein

HMDBP01358

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.527	2
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	2
UniProt:P50990 CCT8	5	CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [cytosol] (R-HSA-390449) CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894)	0.527	2
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.527	2
UniProt:P55209 NP1L1			0.499	3
UniProt:Q9UNF1 MAGED2	2	MAGED2 [platelet alpha granule lumen] (R-HSA-8862956) MAGED2 [extracellular region] (R-HSA-8862948)	0.499	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.488	2