IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1

Stable Identifier
R-HSA-8983300
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
JAK3 is phosphorylated after IL15 stimulation
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Tyrosine-protein kinase JAK1(JAK1) and Tyrosine-protein kinase JAK3 (JAK3) are believed to be phosphorylated after stimulation of the Interleukin-15 receptor complex by Interleukin-15 (IL15) (Johnston et al. 1995), though it has been reported that only JAK3 phosphorylation increases in response to IL15 (Krolopp et al. 2016). The Interleukin-15 receptor complex consists of IL15, Interleukin-15 receptor alpha subunit (IL15RA, IL15Rα), Interleukin-2 receptor beta subunit (IL2RB, IL2Rβ), which is associated with JAK1 and Interleukin receptor gamma subunit, which is associated with JAK3 (Johnston et al. 1995). This is a black box event since the mechanism by which IL15 promotes JAK phosphorylation is unclear.

Literature References
PubMed ID Title Journal Year
7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15

Johnston, JA, Bacon, CM, Finbloom, DS, Rees, RC, Kaplan, D, Shibuya, K, Ortaldo, JR, Gupta, S, Chen, YQ, Giri, JD

Proc Natl Acad Sci U S A 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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