IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1

Stable Identifier
R-HSA-8983309
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Inferred from mouse: Interleukin-15 (IL15) stimulates the phosphorylation of SHC1 bound to Interleukin-2 receptor subunit beta (IL2RB, IL2Rβ) (Zambricki et al 2005), which is a component of the IL15 and IL2 receptor complexes (Bennet et al. 1994, Li et al. 1994). More in detail, human and mouse IL15 have 70.2% amino acid sequence similarity and exhibit similar trans-presentation mechanism, signal transduction machinery and biological activities. Similarly, human IL15 shows cross reactivity with mouse cells and it was demonstrated that human and mouse IL15 showed similar responses in mouse models (Stoklasek et al. 2006) (Patidar et al. data not published).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created