Reactome | GRB2 [cytosol]

GRB2 [cytosol]

Stable Identifier

R-HSA-8983328

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser for interactor UniProt:Q15109 AGER

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External Reference Information

External Reference

UniProt:P62993 GRB2

Gene Names

GRB2, ASH

Chain

chain:1-217

Reference Genes

BioGPS Gene:2885 GRB2

COSMIC (genes):GRB2 GRB2

CTD Gene:2885 GRB2

dbSNP Gene:2885 GRB2

ENSEMBL:ENSG00000177885 GRB2

ENSEMBL_homo_sapiens_GENE:ENSG00000177885.15 GRB2

HGNC:4566 GRB2

KEGG Gene (Homo sapiens):2885 GRB2

Monarch:2885 GRB2

NCBI Gene:2885 GRB2

OMIM:108355 GRB2

UCSC:P62993 GRB2

Reference Transcript

Other Identifiers

11718334_a_at

11741435_s_at

1565_s_at

16848807

215075_PM_s_at

215075_s_at

223049_PM_at

223049_at

2885

33855_at

3770746

3770747

3770748

3770749

3770750

3770751

3770752

3770753

3770754

3770755

3770756

3770757

3770758

3770761

3770772

3770773

3770774

3770777

3770778

46217_at

8018364

A_23_P77847

A_24_P39654

A_24_P407717

GE78983

GE83126

GO:0001784

GO:0002376

GO:0003723

GO:0005068

GO:0005091

GO:0005154

GO:0005168

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005768

GO:0005794

GO:0005829

GO:0005886

GO:0005911

GO:0005938

GO:0007010

GO:0007165

GO:0007173

GO:0007265

GO:0008180

GO:0008286

GO:0008543

GO:0012506

GO:0014044

GO:0016020

GO:0016192

GO:0017124

GO:0019901

GO:0019903

GO:0019904

GO:0023052

GO:0030036

GO:0030154

GO:0030674

GO:0030838

GO:0031410

GO:0031623

GO:0035987

GO:0042552

GO:0042770

GO:0042802

GO:0043226

GO:0043408

GO:0043560

GO:0046875

GO:0048009

GO:0048646

GO:0048856

GO:0050853

GO:0060090

GO:0060670

GO:0065003

GO:0070062

GO:0070436

GO:0071479

GO:0098772

GO:2000379

HMNXSV003047633

Hs.296381.1.A1_3p_a_at

ILMN_1742521

ILMN_1748797

M96995_s_at

PH_hs_0024870

TC17001877.hg

g12005510_3p_at

Participates

as a component of

as an input of

Inferred To

Grb2 [cytosol] (Mus musculus)

Grb2 [cytosol] (Rattus norvegicus)

grb2 [cytosol] (Xenopus tropicalis)

GRB2 [cytosol] (Bos taurus)

GRB2 [cytosol] (Canis familiaris)

GRB2 [cytosol] (Gallus gallus)

GRB2 [cytosol] (Sus scrofa)

drk [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_987102.1, NP_002077.1

OpenTargets

ENSG00000177885

HPA

ENSG00000177885-GRB2

GeneCards

P62993

ZINC - Substances

GRB2_HUMAN

ZINC target

P62993

Ensembl

ENSG00000177885, ENST00000316804, ENST00000648046, ENST00000316615, ENSP00000376347, ENSP00000339007, ENST00000392563, ENST00000392564, ENSP00000376346, ENSP00000317360, ENST00000392562, ENSP00000376345, ENSP00000496913

PRO

P62993

Pharos - Targets

P62993

ZINC - Predictions - Purchasable

GRB2_HUMAN

PDB

3OV1, 3N7Y, 2VWF, 1GFC, 6SDF, 1GFD, 3WA4, 2AOB, 2H46, 3C7I, 3IMJ, 3MXC, 1BMB, 1TZE, 3IMD, 1JYQ, 2VVK, 3KFJ, 3S8N, 6WM1, 1QG1, 1GHU, 4P9Z, 1CJ1, 6ICH, 2W0Z, 2AOA, 8DGO, 1FYR, 6ICG, 7MPH, 3IN8, 2H5K, 6WO2, 1GRI, 1ZFP, 1JYR, 1AZE, 3N84, 4P9V, 5CDW, 3OVE, 1FHS, 1GCQ, 1JYU, 1X0N, 3S8L, 3MXY, 1IO6, 2HUW, 3N8M, 3IN7, 6VK2, 3S8O, 1BM2

Interactors (262)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.983	59
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.976	33
UniProt:Q07889 SOS1	3	p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [plasma membrane] (R-HSA-983559) SOS1 [cytosol] (R-HSA-64847)	0.972	29
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.967	30
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.963	19
UniProt:Q9UQC2 GAB2	5	p-Y643-GAB2 [cytosol] (R-HSA-9677149) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) GAB2 [cytosol] (R-HSA-508239)	0.953	16
UniProt:Q07890 SOS2	1	SOS2 [cytosol] (R-HSA-167221)	0.939	13
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.935	12
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.934	16
UniProt:Q9UJM3 ERRFI			0.934	18
UniProt:Q9H706 GARE1			0.933	13
UniProt:P11274 BCR	4	BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838979) p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839041) BCR(1-584)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604524) BCR [cytosol] (R-HSA-195200)	0.928	13
UniProt:Q13480 GAB1	4	GAB1 [cytosol] (R-HSA-179795) p-5Y-GAB1 [cytosol] (R-HSA-180344) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306)	0.927	13
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.926	10
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.926	10
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.918	18
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.916	8
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.906	12
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.905	11
UniProt:Q9Y4K4 M4K5			0.897	7
UniProt:Q05193 DNM1	3	DNM1 [cytosol] (R-HSA-2213182) DNM1 [lysosomal membrane] (R-HSA-196150) DNM1 [plasma membrane] (R-HSA-177488)	0.87	8
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.868	8
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.863	6
UniProt:Q8TF74 WIPF2	1	WIPF2 [cytosol] (R-HSA-2197666)	0.85	7
UniProt:Q9UKW4 VAV3	2	VAV3 [cytosol] (R-HSA-430152) p-Y173-VAV3 [cytosol] (R-HSA-442287)	0.848	8
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.848	10
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.834	8
UniProt:Q12774 ARHGEF5	1	ARHGEF5 [cytosol] (R-HSA-8873909)	0.82	8
UniProt:P35235 Ptpn11	5	p-Y546,Y584-Shp2 [cytosol] (R-MMU-443116) Ptpn11 [cytosol] (R-MMU-210002) PTPN11 [nucleoplasm] (R-MMU-8937745) PTPN11 [cytosol] (R-MMU-162563) phospho-p-Y542,Y580-PTPN11 [cytosol] (R-MMU-162573)	0.809	7
UniProt:Q14185 DOCK1	1	DOCK1 [cytosol] (R-HSA-372654)	0.809	6
UniProt:O43516 WIPF1	1	WIPF1 [cytosol] (R-HSA-201874)	0.804	5
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.802	6
UniProt:P42336 PIK3CA	20	PIK3CA H1047L [cytosol] (R-HSA-1500714) PIK3CA H1047R [cytosol] (R-HSA-1500716) PIK3CA M1043I [cytosol] (R-HSA-1500719) PIK3CA M1043T [cytosol] (R-HSA-2395934) PIK3CA M1043V [cytosol] (R-HSA-2395932) PIK3CA H1047Y [cytosol] (R-HSA-1500720) PIK3CA E542K [cytosol] (R-HSA-1500701) PIK3CA Q546K [cytosol] (R-HSA-1500705) PIK3CA E545A [cytosol] (R-HSA-2362355) PIK3CA E545K [cytosol] (R-HSA-1500706) PIK3CA E545Q [cytosol] (R-HSA-2362362) PIK3CA Q546E [cytosol] (R-HSA-2362383) PIK3CA E545V [cytosol] (R-HSA-2362365) PIK3CA E542V [cytosol] (R-HSA-2328074) PIK3CA Q546L [cytosol] (R-HSA-2362375) PIK3CA E545G [cytosol] (R-HSA-1500709) PIK3CA Q546H [cytosol] (R-HSA-2362374) PIK3CA Q546R [cytosol] (R-HSA-2362373) PIK3CA Q546P [cytosol] (R-HSA-1500695) PIK3CA E542Q [cytosol] (R-HSA-2328003)	0.8	6
UniProt:Q6ZUJ8 PIK3AP1	1	p-4Y-PIK3AP1 [plasma membrane] (R-HSA-984814)	0.798	6
UniProt:Q9UKT9 IKZF3			0.795	8
UniProt:Q8N1K5 THMS1			0.794	11
UniProt:Q92918 M4K1			0.782	9
UniProt:O43150 ASAP2			0.752	4
UniProt:Q8WV28 BLNK	2	BLNK [cytosol] (R-HSA-912750) p-5Y-BLNK [plasma membrane] (R-HSA-983579)	0.743	5
UniProt:P10721 KIT	20	KIT C443Y [plasma membrane] (R-HSA-9680045) KIT T417_D419delinsY [plasma membrane] (R-HSA-9680110) KIT S476I [plasma membrane] (R-HSA-9680090) KIT K509I [plasma membrane] (R-HSA-9680177) KIT D419A [plasma membrane] (R-HSA-9680051) KIT D419del [plasma membrane] (R-HSA-9680079) KIT S501_A502dup [plasma membrane] (R-HSA-9680105) KIT D419G [plasma membrane] (R-HSA-9680057) KIT N505_F508dup [plasma membrane] (R-HSA-9680085) KIT C443S [plasma membrane] (R-HSA-9680038) KIT D419N [plasma membrane] (R-HSA-9680071) KIT S476N [plasma membrane] (R-HSA-9680097) KIT D419H [plasma membrane] (R-HSA-9680066) KIT V560_L576del [plasma membrane] (R-HSA-9670336) KIT Y823N [plasma membrane] (R-HSA-9669591) KIT Y823C [plasma membrane] (R-HSA-9669585) p6Y-KIT Y823D [plasma membrane] (R-HSA-9669628) p7Y-KIT D816V [plasma membrane] (R-HSA-9669612) p7Y-KIT K642E [plasma membrane] (R-HSA-9669596) p7Y-KIT N822K [plasma membrane] (R-HSA-9669617)	0.743	6
UniProt:Q8IUW3 SPA2L			0.742	5
UniProt:Q8N1I0 DOCK4	1	DOCK4 [cytosol] (R-HSA-1012995)	0.738	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.738	5
UniProt:P35570 Irs1	7	Irs1 [cytosol] (R-RNO-1168867) phospho-Irs1 [plasma membrane] (R-RNO-2445090) Irs1 [plasma membrane] (R-RNO-2425392) p-Y-Irs1 [cytosol] (R-RNO-112362) Irs1 [cytosol] (R-RNO-74769) phospho-Irs1 [cytosol] (R-RNO-74772) phospho-Irs1 [plasma membrane] (R-RNO-198366)	0.737	5
UniProt:Q07912 TNK2	1	TNK2 [cytosol] (R-HSA-9842568)	0.737	5
UniProt:P21802 FGFR2	20	FGFR2 IIIa TM [extracellular region] (R-HSA-8851703) FGFR2 [plasma membrane] (R-HSA-2023840) FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane] (R-HSA-8853137) FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane] (R-HSA-8853154) FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane] (R-HSA-8853123) FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane] (R-HSA-8853158) FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane] (R-HSA-8853150) FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane] (R-HSA-8853153) FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane] (R-HSA-8853139) FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane] (R-HSA-8853159) FGFR2 N549H [plasma membrane] (R-HSA-2033296) FGFR2 N549K [plasma membrane] (R-HSA-1637910) FGFR2 K660N [plasma membrane] (R-HSA-1637905) FGFR2 K660M [plasma membrane] (R-HSA-1637902) FGFR2 K660E [plasma membrane] (R-HSA-1637900) FGFR2 S267P [plasma membrane] (R-HSA-1637920) FGFR2 L764Hfs*4 [plasma membrane] (R-HSA-1637908) FGFR2 W290C [plasma membrane] (R-HSA-1637929) p-6Y-FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane] (R-HSA-8853134) p-6Y-FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane] (R-HSA-8853146)	0.735	6
UniProt:Q96P48 ARAP1	2	ARAP1 [cytosol] (R-HSA-3211582) p-Y231-ARAP1 [cytosol] (R-HSA-8848869)	0.725	5
UniProt:A6NGB9 WIPF3	1	WIPF3 [cytosol] (R-HSA-2197670)	0.725	5
UniProt:Q96JJ3 ELMO2	1	ELMO2 [cytosol] (R-HSA-372642)	0.725	5
UniProt:B7ZLH0 B7ZLH0			0.718	6
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.713	4
UniProt:Q14457 BECN1	4	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.709	8
UniProt:O43561 LAT	3	p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829) p-5Y-LAT [plasma membrane] (R-HSA-202364) LAT [plasma membrane] (R-HSA-202322)	0.708	7
UniProt:Q62245 Sos1	4	phospho-Sos1 [cytosol] (R-MMU-109821) Sos1 [cytosol] (R-MMU-443318) Sos1 [plasma membrane] (R-MMU-983559) Sos1 [cytosol] (R-MMU-64847)	0.704	4
UniProt:Q08209 PPP3CA	2	PPP3CA [nucleoplasm] (R-HSA-2685599) PPP3CA [cytosol] (R-HSA-201771)	0.678	3
UniProt:P21860 ERBB3			0.678	5
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.676	3
UniProt:Q16643 DBN1	1	DBN1 [cytosol] (R-HSA-9714666)	0.674	4
UniProt:P11137 MTAP2			0.672	7
UniProt:O60636 TSN2			0.672	6
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.666	4
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.666	4
UniProt:Q9H788 SH24A			0.666	4
UniProt:Q0VD86 INCA1			0.666	4
UniProt:Q9Y2W2 WBP11	1	WBP11 [nucleoplasm] (R-HSA-8867887)	0.666	4
UniProt:Q06418 TYRO3			0.666	4
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.666	4
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.665	3
UniProt:P15498 VAV1	5	p-Y-VAV1 [cytosol] (R-HSA-9029087) VAV1 [plasma membrane] (R-HSA-1045153) VAV1 [cytosol] (R-HSA-195066) p-Y174-VAV1 [cytosol] (R-HSA-437946) p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323)	0.665	3
UniProt:P98078	3	Dab2 [cytosol] (R-MMU-8862456) Dab2 [lysosomal membrane] (R-MMU-2980807) Dab2 [plasma membrane] (R-MMU-2980808)	0.662	4
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.659	3
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.659	4
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.659	4
UniProt:Q05397 PTK2	11	pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.659	4
UniProt:O00459 PIK3R2	3	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554) p-Y464-PIK3R2 [cytosol] (R-HSA-9860512)	0.659	4
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.659	3
UniProt:Q13905 RAPGEF1	2	RAPGEF1 [cytosol] (R-HSA-913472) RAPGEF1 [endosome] (R-HSA-3008667)	0.658	3
UniProt:P27958 POLG	1	POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HCV-8854138)	0.656	3
UniProt:P29350 PTPN6	5	PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.646	3
UniProt:Q9UQ16 DNM3	2	DNM3 [cytosol] (R-HSA-2213188) DNM3 [plasma membrane] (R-HSA-443610)	0.643	4
UniProt:Q9H7D0 DOCK5	1	DOCK5 [cytosol] (R-HSA-1012991)	0.643	4
UniProt:P23469 PTPRE			0.643	3
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.643	4
UniProt:P42338 PIK3CB	1	PIK3CB [cytosol] (R-HSA-74788)	0.643	3
UniProt:Q9H792 PEAK1	1	PEAK1 [cytosol] (R-HSA-9715162)	0.643	3
UniProt:O43426 SYNJ1	1	SYNJ1 [cytosol] (R-HSA-1604634)	0.643	3
UniProt:Q75VX8 GARE2			0.643	3
UniProt:Q38SD2 LRRK1			0.643	3
UniProt:Q14247 CTTN	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.643	3
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.642	4
UniProt:Q8N1K5-1 THEMIS			0.639	10
UniProt:O14939 PLD2	2	PLD2 [plasma membrane] (R-HSA-2029075) PLD2 [endoplasmic reticulum membrane] (R-HSA-1498791)	0.635	4
UniProt:Q15027 ACAP1			0.635	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.615	4
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.61	4
UniProt:O14672 ADAM10	6	ADAM10(215-824) [plasma membrane] (R-HSA-179885) ADAM10 [plasma membrane] (R-HSA-157237) ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956768) p-ADAM10 [endoplasmic reticulum lumen] (R-HSA-8956999) ADAM10 [tertiary granule membrane] (R-HSA-6800992) ADAM10 [specific granule membrane] (R-HSA-6799566)	0.602	5
UniProt:Q8NFH8 REPS2	1	REPS2 [cytosol] (R-HSA-432938)	0.602	8
UniProt:P30530 AXL	2	p-Y779,Y821-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.597	4
UniProt:P34152 Ptk2	13	phospho-pY-PTK2 [cytosol] (R-MMU-9632393) phospho-p-6Y-PTK2 [cytosol] (R-MMU-354128) phospho-p-Y397-PTK2 [cytosol] (R-MMU-354068) PTK2 [cytosol] (R-MMU-201621) PTK2(1-772) [cytosol] (R-MMU-202827) PTK2(773-1052) [cytosol] (R-MMU-202829) phospho-p-6Y,S732-PTK2 [cytosol] (R-MMU-5218694) phospho-p-5Y,S732-PTK2 [cytosol] (R-MMU-5229006) phospho-p-5Y-PTK2 [cytosol] (R-MMU-5218711) Fak1 [cytosol] (R-MMU-3928448) p-Y428-FAK1 [cytosol] (R-MMU-3928397) phospho-p-Y194,Y397-PTK2 [cytosol] (R-MMU-8874600) phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-MMU-8874613)	0.597	3
UniProt:O15357 INPPL1	1	INPPL1 [cytosol] (R-HSA-913354)	0.597	4
UniProt:Q9ESJ4	1	Nckipsd [cytosol] (R-MMU-2197671)	0.593	8
UniProt:Q5SQ64 LY6G6F	2	LY6G6F [plasma membrane] (R-HSA-8862974) LY6G6F [platelet alpha granule membrane] (R-HSA-8862968)	0.591	3
UniProt:O43597 SPRY2	8	p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629) p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55-SPRY2 [cytosol] (R-HSA-182950) SPRY2 [plasma membrane] (R-HSA-182924) SPRY2 [cytosol] (R-HSA-182949) p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595)	0.591	3
UniProt:O92972 POLG			0.589	2
UniProt:Q15303 ERBB4			0.573	7
UniProt:O14490 DLGAP1	1	DLGAP1 [plasma membrane] (R-HSA-6794239)	0.573	3
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.573	2
UniProt:Q8IVH8 M4K3			0.573	2
UniProt:O15056 SYNJ2	1	SYNJ2 [cytosol] (R-HSA-1806193)	0.573	2
UniProt:P98082 DAB2	3	DAB2 [cytosol] (R-HSA-8862456) DAB2 [lysosomal membrane] (R-HSA-2980807) DAB2 [plasma membrane] (R-HSA-2980808)	0.573	2
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [secretory granule lumen] (R-HSA-6801039) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [cytosol] (R-HSA-1181251)	0.57	3
UniProt:Q8WXH5 SOCS4	1	SOCS4 [cytosol] (R-HSA-8936109)	0.57	3
UniProt:Q8TE12 LMX1A			0.57	3
UniProt:Q5BJH2-2 TMEM128			0.57	3
UniProt:Q07869 PPARA	2	monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099) PPARA [nucleoplasm] (R-HSA-400186)	0.57	3
UniProt:Q9NPB6-2 PARD6A			0.57	3
UniProt:P14868 DARS1	1	DARS [cytosol] (R-HSA-379605)	0.564	2
UniProt:P21333 FLNA	3	FLNA [extracellular region] (R-HSA-350712) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019)	0.564	2
UniProt:P19174 PLCG1	6	p-Y-PLCG1 [cytosol] (R-HSA-9029082) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084)	0.564	2
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.564	2
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.564	2
UniProt:Q9H0X6 RN208			0.556	3
UniProt:Q9BWF3-2 RBM4			0.556	3
UniProt:Q9NRF2-2 SH2B1	1	SH2B1-2 [cytosol] (R-HSA-1675482)	0.556	3
UniProt:Q7Z783 Q7Z783			0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q13829 TNFAIP1	1	TNFAIP1 [cytosol] (R-HSA-9696531)	0.556	3
UniProt:Q14693 LPIN1	3	p-S106-LPIN1 [nucleoplasm] (R-HSA-4419936) LPIN1 [nuclear envelope] (R-HSA-4419927) LPIN1 [endoplasmic reticulum membrane] (R-HSA-549157)	0.556	3
UniProt:Q6P1W5 CA094			0.556	3
UniProt:Q9P2A4 ABI3			0.556	3
UniProt:Q13352 ITGB3BP	2	ITGB3BP [cytosol] (R-HSA-3006405) ITGB3BP [nucleoplasm] (R-HSA-606325)	0.556	3
UniProt:Q9NQC1-2 JADE2			0.556	3
UniProt:Q9UI10 EIF2B4	1	EIF2B4 [cytosol] (R-HSA-72521)	0.556	3
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.556	3
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:P52566 ARHGDIB	1	ARHGDIB [cytosol] (R-HSA-195081)	0.556	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:Q9BUN5-3 CCDC28B			0.556	3
UniProt:Q12929 EPS8	1	EPS8 [cytosol] (R-HSA-9662382)	0.556	3
UniProt:Q86UU5 GGN			0.556	3
UniProt:Q9BYN7 ZN341			0.556	3
UniProt:Q3LI72 KRTAP19-5	1	KRTAP19-5 [cytosol] (R-HSA-6810300)	0.556	3
UniProt:Q6DHY5 TBC3G			0.556	3
UniProt:Q96RU7 TRIB3	3	TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [cytosol] (R-HSA-162411) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.556	3
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.556	3
UniProt:Q8NFB2 T185A			0.556	3
UniProt:Q8IX15-3 HOMEZ			0.556	3
UniProt:Q6XD76 ASCL4			0.556	3
UniProt:P42681 TXK	3	TXK [cytosol] (R-HSA-3448733) p-Y91,Y420-TXK [cytosol] (R-HSA-3448740) p-Y420-TXK [cytosol] (R-HSA-3448734)	0.556	3
UniProt:O95994 AGR2			0.556	5
UniProt:A0JLT2-2 MED19			0.556	3
UniProt:Q92558 WASF1	3	WASF1 [cytosol] (R-HSA-200965) p-Y151,S,T-WASF1 [cytosol] (R-HSA-5672390) p-Y151-WASF1 [cytosol] (R-HSA-2029058)	0.556	3
UniProt:Q7L190 DPPA4	1	DPPA4 [nucleoplasm] (R-HSA-452999)	0.556	3
UniProt:Q6ZU52 K0408			0.556	3
UniProt:Q8N4B1-4 PHETA1			0.556	3
UniProt:Q03989 ARI5A			0.556	3
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q6ZNG0 ZNF620	1	ZNF620 [nucleoplasm] (R-HSA-2127603)	0.556	3
UniProt:Q9Y330 ZBT12			0.556	5
UniProt:Q6IQ23-2 PLEKHA7			0.556	3
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.556	3
UniProt:Q8N9I9 DTX3			0.556	3
UniProt:Q86SG2 ANR23			0.556	3
UniProt:Q9BRR9 ARHGAP9	3	ARHGAP9 [cytosol] (R-HSA-2976572) ARHGAP9 [extracellular region] (R-HSA-6806529) ARHGAP9 [secretory granule lumen] (R-HSA-6804973)	0.556	3
UniProt:Q9HB07 MYG1			0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q9BRT8 ZNG1A			0.556	3
UniProt:Q9GZT8 NIF3L			0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:A8MW99 MEI4			0.556	3
UniProt:B1AHC3 B1AHC3			0.556	3
UniProt:Q8N684-3 CPSF7			0.556	3
IntAct:EBI-22412087 CCSB ORF ID			0.556	3
IntAct:EBI-10220116 163154			0.556	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:Q9UNY5 ZN232			0.556	3
UniProt:Q6S9Z5 ZN474			0.556	3
UniProt:P62324 BTG1	1	BTG1 [nucleoplasm] (R-HSA-9620886)	0.556	3
UniProt:Q96PV4 PNMA5			0.556	3
UniProt:O14512 SOCS7			0.556	3
UniProt:Q13625-3 TP53BP2			0.556	3
UniProt:Q13322-4 GRB10			0.556	3
UniProt:Q5JST6 EFHC2			0.556	3
UniProt:O15156 ZBT7B			0.556	3
UniProt:Q15907 RAB11B	3	RAB11B [recycling endosome membrane] (R-HSA-8854762) GGC-RAB11B [cytosol] (R-HSA-8873766) RAB11B [cytosol] (R-HSA-8873671)	0.556	3
UniProt:Q92841 DDX17	2	DDX17 [nucleoplasm] (R-HSA-3900090) monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104)	0.556	3
UniProt:P48634 PRC2A			0.553	2
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.553	2
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.553	2
UniProt:Q5JSH3 WDR44			0.547	2
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.547	2
UniProt:Q01082 SPTBN1	3	SPTBN1(2-159)-FLT3(570-993) fusion [cytosol] (R-HSA-9703316) SPTBN1(2-159)-p-6Y-FLT3(570-993) fusion [cytosol] (R-HSA-9703317) SPTBN1 [cytosol] (R-HSA-420048)	0.547	2
UniProt:P05787 KRT8	1	KRT8 [cytosol] (R-HSA-446043)	0.547	3
UniProt:Q92734 TFG	7	TFG(1-138)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702019) TFG(1-240)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702038) TFG(1-193)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9702029) TFG(1-193)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699887) TFG(1-138)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699874) TFG(1-240)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699806) TFG [cytosol] (R-HSA-5688159)	0.547	2
UniProt:O75083 WDR1	2	WDR1 [extracellular region] (R-HSA-350752) WDR1 [cytosol] (R-HSA-350699)	0.547	2
UniProt:Q06187 BTK	6	p-Y223,Y551-BTK [cytosol] (R-HSA-2424454) Active BTK [cytosol] (R-HSA-8964323) p-Y551-BTK [cytosol] (R-HSA-2685603) BTK [cytosol] (R-HSA-197948) p-Y551-BTK [plasma membrane] (R-HSA-9606165) p-Y223,Y551-BTK [plasma membrane] (R-HSA-984807)	0.547	2
UniProt:O43295 SRGAP3	1	SRGAP3 [cytosol] (R-HSA-428463)	0.544	2
UniProt:Q9Y2R2 PTPN22	1	PTPN22 [cytosol] (R-HSA-8852205)	0.544	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	3
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.527	3
UniProt:P14618 PKM	3	PKM [secretory granule lumen] (R-HSA-6801401) PKM [extracellular region] (R-HSA-6806491) PKM [ficolin-1-rich granule lumen] (R-HSA-6801387)	0.527	2
UniProt:Q9UQ16-2 DNM3			0.527	2
UniProt:P62937 PPIA	5	PPIA [extracellular exosome] (R-HSA-6801538) PPIA [secretory granule lumen] (R-HSA-6801400) PPIA [extracellular region] (R-HSA-173646) PPIA [ficolin-1-rich granule lumen] (R-HSA-6801391) PPIA [cytosol] (R-HSA-173123)	0.527	2
UniProt:Q99816 TSG101	1	TSG101 [endosome membrane] (R-HSA-2980549)	0.527	3
UniProt:Q9UK41 VPS28	1	VPS28 [endosome membrane] (R-HSA-184342)	0.527	2
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.527	2
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.527	2
UniProt:P05141 SLC25A5	1	SLC25A5 [mitochondrial inner membrane] (R-HSA-49743)	0.527	3
UniProt:P27708 CAD	1	CAD [cytosol] (R-HSA-73452)	0.527	3
UniProt:P41240 CSK	2	CSK [plasma membrane] (R-HSA-180499) CSK [cytosol] (R-HSA-203776)	0.527	2
UniProt:O95789 ZMYM6			0.527	2
UniProt:P12236 SLC25A6	2	SLC25A6 [mitochondrial inner membrane] (R-HSA-49745) SLC25A6 [mitochondrial intermembrane space] (R-HSA-1955374)	0.527	2
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	3
UniProt:Q93079 H2BC9	9	Ub-HIST1H2BH [nucleoplasm] (R-HSA-6782558) AcK-HIST1H2BH [nucleoplasm] (R-HSA-4549241) HIST1H2BH [extracellular region] (R-HSA-977580) AcK16-HIST1H2BH [nucleoplasm] (R-HSA-4568682) AcK6-HIST1H2BH [nucleoplasm] (R-HSA-4568718) AcK21-HIST1H2BH [nucleoplasm] (R-HSA-4568657) AcK13-HIST1H2BH [nucleoplasm] (R-HSA-4568705) Ub-121-HIST1H2BH [nucleoplasm] (R-HSA-3364021) HIST1H2BH [nucleoplasm] (R-HSA-181915)	0.527	2
UniProt:Q96EY5 MVB12A	1	MVB12A [endosome membrane] (R-HSA-8955360)	0.527	2
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [extracellular exosome] (R-HSA-8950304) HNRNPA2B1 [nucleoplasm] (R-HSA-71929)	0.527	2
UniProt:Q9NZQ3 NCKIPSD	1	NCKIPSD [cytosol] (R-HSA-2197671)	0.527	2
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.527	3
UniProt:P19105 MYL12A	2	p-S19-MYL12A [cytosol] (R-HSA-390749) MYL12A [cytosol] (R-HSA-390735)	0.527	2
UniProt:Q8TF42 UBS3B			0.527	3
UniProt:Q00325 S25A3			0.527	2
UniProt:P52952 NKX2-5	1	NKX2-5 [nucleoplasm] (R-HSA-4005994)	0.527	2
UniProt:Q96RF0 SNX18	1	SNX18 [cytosol] (R-HSA-8868038)	0.527	2
UniProt:Q96RF0-2 SNX18			0.527	2
UniProt:A5YM69 ARHGEF35	1	ARHGEF35 [cytosol] (R-HSA-8871615)	0.527	3
UniProt:Q13480-2 GAB1			0.527	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	3
UniProt:Q9H939 PPIP2			0.527	2
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.527	2
UniProt:P13639 EEF2	10	EEF2 [ficolin-1-rich granule lumen] (R-HSA-6801513) EEF2 [extracellular region] (R-HSA-6806499) EEF2 [secretory granule lumen] (R-HSA-6801504) EEF2 [cytosol] (R-HSA-156901) aminocarboxypropyl EEF2 [cytosol] (R-HSA-5358478) Me-diphthine EEF2 [cytosol] (R-HSA-5367025) nascent EEF2 [cytosol] (R-HSA-5358472) diphthine EEF2 [cytosol] (R-HSA-5358501) ADP-ribo-EEF2 [cytosol] (R-HSA-5334764) Me3K525-EEF2 [cytosol] (R-HSA-8932237)	0.527	2
UniProt:P07355 ANXA2	6	ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [external side of plasma membrane] (R-HSA-5336164) p-Y24,S26-ANXA2 [cytosol] (R-HSA-9865224) p-S26-ANXA2 [cytosol] (R-HSA-9865163) ANXA2 [extracellular region] (R-HSA-6806242) ANXA2 [azurophil granule lumen] (R-HSA-6798766)	0.527	2
UniProt:P29353-1 SHC1	4	SHC1 [plasma membrane] (R-HSA-2404179) SHC1-1 [cytosol] (R-HSA-1433366) p-S139,3Y-SHC1-1 [cytosol] (R-HSA-8934452) p-Y349,Y350,Y427-SHC1-1 [cytosol] (R-HSA-2404176)	0.524	3
UniProt:P26662-PRO_0000037647			0.524	3
UniProt:O75674 TM1L1			0.524	2
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653)	0.524	2
UniProt:Q7L0Q8 RHOU	4	p-Y254-RHOU [endosome membrane] (R-HSA-9726860) p-Y254-RHOU [plasma membrane] (R-HSA-9726857) RHOU [plasma membrane] (R-HSA-194914) RHOU [cytosol] (R-HSA-194901)	0.524	3
UniProt:Q5SXH7-1 PLEKHS1			0.508	2
UniProt:Q66PJ3-4 ARL6IP4			0.508	2
UniProt:Q16236 NFE2L2	13	p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-NFE2L2 [cytosol] (R-HSA-9758077) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.508	2
UniProt:Q9Y478 PRKAB1	2	PRKAB1 [cytosol] (R-HSA-380968) PRKAB1 [nucleoplasm] (R-HSA-2151199)	0.508	2
UniProt:P54762 EPHB1	6	EPHB1 (?-?) [plasma membrane] (R-HSA-3928449) EPHB1 (?-984) [cytosol] (R-HSA-3928438) EPHB1 (?-984) [plasma membrane] (R-HSA-3928402) EPHB1 (18-?) [extracellular region] (R-HSA-3928393) p-Y594,Y600-EPHB1 [plasma membrane] (R-HSA-3928347) EPHB1 [plasma membrane] (R-HSA-2682340)	0.499	2
UniProt:Q810M5 ZDH19			0.499	2
UniProt:Q7VLE8 Q7VLE8			0.499	2
UniProt:Q8N7B6-2 PACRGL			0.488	2
UniProt:Q9H7T9 AUNIP			0.488	2
UniProt:Q96D37 Q96D37			0.488	2
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.488	2
UniProt:Q9NP98 MYOZ1			0.488	2
UniProt:Q9Y5E4 PCDB5			0.488	2
UniProt:Q96ID7 Q96ID7			0.488	2
UniProt:Q9BRT2 UQCC2	1	UQCC2 [mitochondrial inner membrane] (R-HSA-9865900)	0.488	2
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.488	2
UniProt:Q8IZQ1 WDFY3			0.488	2
UniProt:Q96SW2-2 CRBN			0.488	2
UniProt:Q8N448 LNX2			0.488	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:P09619 PDGFRB	3	p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) PDGFRB [plasma membrane] (R-HSA-186767) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.462	2
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.462	3
UniProt:P12497-PRO_0000042399 GAG-POL			0.462	3
UniProt:A9UF07 A9UF07			0.462	6

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