IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome

Stable Identifier
R-HSA-8983335
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
Internalization IL15-IL15Ralpha
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The formation of Interleukin-15/Interleukin-15 receptor alpha complexes (IL15:IL15RA or IL15: IL15Rα) on cell surfaces induce a trans-endosomal recycling of IL15 leading to the persistence of surface-bound IL15 due to the constant reappearance of IL15 on plasma membranes. This complex contributes to the long survival of T cells expressing IL15RA after IL15 withdrawal (Dubois et al. 2000). This is a black box event since the details of other potential receptors and proteins participating in this event, remain unclear. It is shown similar patterns for other interleukins (i.e: Interleukin-12, Chiaruttini et al. 2016).

Literature References
PubMed ID Title Journal Year
12433361 IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

Dubois, S, Mariner, J, Waldmann, TA, Tagaya, Y

Immunity 2002
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Orthologous Events
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