p-Y-STAT3:p-STAT5 translocates to the nucleus

Stable Identifier
R-HSA-8983379
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
Synonyms
p-STAT3:p-STAT5A,p-STAT5B translocates to the nucleus
ReviewStatus
5/5
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p-Y-STAT3:p-STAT5 translocates to the nucleus
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Signal transducer and activator of transcription 3 (STAT3) and Signal transducer and activator of transcription 5A/5B (STAT5A and STAT5B respectively or STAT5) dimers translocate from the cytosol to the nucleoplasm. 10 ng/mL Interleukin-15 (IL15) induces the nuclear localization of phosphorylated STAT3, unless inhibited by neutralizing anti-IL15 or anti-Interleukin receptor alpha subunit (IL15RA, IL15Rα) mAbs (Giron Michel et al.2003, Johnston et al. 1995).This is a black box event because nuclear translocation of phosphorylated STAT3:STAT5 dimers has not been demonstrated but is inferred from other Jak-Stat signaling events.
Literature References
PubMed ID Title Journal Year
12623850 Differential STAT3, STAT5, and NF-kappaB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules

van Dijk, M, Clay, D, Fogli, M, Chouaib, S, Bompais, H, Lebousse-Kerdilès, C, Briard, D, Ferrini, S, Azzarone, B, Meazza, R, Péault, B, Caignard, A, Brouty-Boyé, D, Giron-Michel, J

Blood 2003
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Orthologous Events
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p-Y-STAT3:p-STAT5 translocates to the nucleus (Dictyostelium discoideum)
p-Y-STAT3:p-STAT5 translocates to the nucleus (Drosophila melanogaster)
p-Y-STAT3:p-STAT5 translocates to the nucleus (Gallus gallus)
p-Y-STAT3:p-STAT5 translocates to the nucleus (Mus musculus)
p-Y-STAT3:p-STAT5 translocates to the nucleus (Rattus norvegicus)
p-Y-STAT3:p-STAT5 translocates to the nucleus (Sus scrofa)
p-Y-STAT3:p-STAT5 translocates to the nucleus (Xenopus tropicalis)
Authored
Duenas, C  (2017-08-07)
Reviewed
Patidar, M  (2017-08-07)
Created
Duenas, C  (2017-03-23)
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