Reactome | IL35 binds IL12RB2:IL12RB2 receptor

IL35 binds IL12RB2:IL12RB2 receptor

Stable Identifier

R-HSA-8983519

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region, cytosol

ReviewStatus

5/5

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Interleukin 35 (IL35) is a heteromeric complex conformed by Interleukin 12 subunit alpha (IL12A) and Interleukin 27 subunit alpha (IL27). IL35 may presumably stimulate Janus Kinase (JAK) bound homodimers of Interleukin 12 receptor beta 2 (IL12RB2). JAKs are believed to be associated with the receptor before receptor activation (Behrmann et al., 2004). Subsequently, this triggers the phosphorylation of STAT4 downstream. The physiological consequence of this signalling is the suppression of T cell response. The event is represented as a black box due to the incomplete knowledge about the ligand binding to monomers followed by dimerization or binding directly to the dimers.

Literature References

PubMed ID	Title	Journal	Year
12829785	Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex Chow, DC, Boulanger, MJ, Garcia, KC, Brevnova, EE	Science	2003
22306691	The composition and signaling of the IL-35 receptor are unconventional Delgoffe, GM, Murray, PJ, Drake, CG, Satoskar, AR, Fairweather, D, Guy, CS, Hunter, CA, Vignali, DA, Garcia, KC, Chaturvedi, V, Collison, LW, Vignali, KM	Nat. Immunol.	2012