p-STAT1 dissociates from IL6ST:IL6ST

Stable Identifier
R-HSA-8983845
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Interleukin-35 (IL35) can signal via IL35 receptors triggering the JAK/STAT pathway downstream. Signal transducer and activator of transcription 1-alpha/beta (STAT1) binds to the JAK associated-IL35 receptor complex and is activated via phosphorylations. Subsequently, phosphorylated p-STAT1 dissociates from the receptor complex (Collison et al. 2012). This is a black box event because there is no literature evidence about the exact mechanism of the release of STAT1 from the receptor complex.

Literature References
PubMed ID Title Journal Year
22306691 The composition and signaling of the IL-35 receptor are unconventional

Collison, LW, Delgoffe, GM, Guy, CS, Vignali, KM, Chaturvedi, V, Fairweather, D, Satoskar, AR, Garcia, KC, Hunter, CA, Drake, CG, Murray, PJ, Vignali, DA

Nat. Immunol. 2012
Participants
Participant Of
Orthologous Events
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Created