Reactome | JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated

JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated

Stable Identifier

R-HSA-8983870

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated

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Interleukin 35 (IL35) may presumably signal via a complex that includes Tyrosine protein kinase JAK2 (JAK2) associated with Interleukin 12 receptor beta 2 (IL12RB2) dimers (Collison et al. 2012). JAKs are believed to phosphorylate Signal transducers and activator of transcription (STATs) (Stark GR and Darnell JE, 2012). As the series of events that induce JAK/STAT phosphorylation events in response to IL35 are not clear, this event is represented as a black box.

Literature References

PubMed ID	Title	Journal	Year
22306691	The composition and signaling of the IL-35 receptor are unconventional Delgoffe, GM, Murray, PJ, Drake, CG, Satoskar, AR, Fairweather, D, Guy, CS, Hunter, CA, Vignali, DA, Garcia, KC, Chaturvedi, V, Collison, LW, Vignali, KM	Nat. Immunol.	2012