Reactome | p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor

p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor

Stable Identifier

R-HSA-8984023

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor

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Interleukin 35 (IL35) can signal via IL35 receptors triggering the JAK/STAT pathway downstream. Signal transducer and activator of transcription 1 alpha/beta (STAT1) and Signal transducer and activator of transcription 3 alpha/beta (STAT3) bind to the JAK associated IL35 receptor complex and are activated via phosphorylations. Subsequently, phosphorylated p STAT1:p STAT3 dissociates from the receptor complex (Wang et al. 2014). This is a black box event because there is no literature evidence about the exact mechanism of the release of STAT1 and STAT3 from the receptor complex.

Literature References

PubMed ID	Title	Journal	Year
24572363	IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases Kaufmann, SH, Grützkau, A, Grün, JR, Lampropoulou, V, Li, R, Boudinot, P, Ries, S, Wirtz, S, Bar-Or, A, Shen, P, Meinl, E, Roch, T, McPherson, RC, Anderton, SM, Jaimes, Y, Hoehlig, K, Jouneau, L, Dörner, T, Leech, MD, Horn, K, Kühl, AA, Daridon, C, Sakwa, I, O'Connor, RA, Dang, VD, Stervbo, U, Neurath, M, Wilantri, S, Hilgenberg, E, Miyazaki, Y, Fillatreau, S	Nature	2014
24743305	Interleukin-35 induces regulatory B cells that suppress autoimmune disease Kim, SH, Wingfield, PT, Mahdi, RM, Dambuza, IM, Yu, CR, Wang, RX, Sergeev, YV, Egwuagu, CE, Dolinska, MB	Nat. Med.	2014