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Interleukin-35 Signalling
Stable Identifier
R-HSA-8984722
DOI
10.3180/R-HSA-8984722.2
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-35 Signalling (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
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|
SBGN
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Interleukin 35 (IL35) is an IL12 family cytokine produced by regulatory but not effector T-cells. It is a dimeric protein composed of IL-12RB2 and IL27RA chains. IL35 suppresses inflammatory responses of immune cells.
Literature References
PubMed ID
Title
Journal
Year
26279360
Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases
Yu, CR
,
Wang, R
,
Egwuagu, CE
,
Sun, L
Cytokine Growth Factor Rev.
2015
Participants
Events
EBI3:CANX binds IL12A
(Homo sapiens)
CANX dissociates from IL12A:EBI3
(Homo sapiens)
Interleukin-35 translocates from the ER lumen to the extracellular region
(Homo sapiens)
IL35 binds IL27RA:IL12RB2 receptor
(Homo sapiens)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
(Homo sapiens)
STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
(Homo sapiens)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
(Homo sapiens)
p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
(Homo sapiens)
IL35 binds IL12RB2:IL12RB2 receptor
(Homo sapiens)
JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
(Homo sapiens)
STAT4 binds IL12RB2:IL12RB2
(Homo sapiens)
JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
(Homo sapiens)
p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
(Homo sapiens)
IL35 binds IL6ST:IL6ST receptor
(Homo sapiens)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
(Homo sapiens)
STAT1 associates with IL6ST:IL6ST
(Homo sapiens)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
(Homo sapiens)
p-STAT1 dissociates from IL6ST:IL6ST
(Homo sapiens)
IL35 binds IL-12RB2:IL6ST receptor
(Homo sapiens)
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
(Homo sapiens)
STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
(Homo sapiens)
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
(Homo sapiens)
p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
(Homo sapiens)
p-STAT1:p-STAT4 translocates to the nucleus
(Homo sapiens)
EBI3 gene transcription and translation
(Homo sapiens)
IL12A gene transcription and translation
(Homo sapiens)
Participates
as an event of
Interleukin-12 family signaling (Homo sapiens)
Event Information
Go Biological Process
interleukin-35-mediated signaling pathway (0070757)
Orthologous Events
Interleukin-35 Signalling (Bos taurus)
Interleukin-35 Signalling (Caenorhabditis elegans)
Interleukin-35 Signalling (Canis familiaris)
Interleukin-35 Signalling (Dictyostelium discoideum)
Interleukin-35 Signalling (Drosophila melanogaster)
Interleukin-35 Signalling (Gallus gallus)
Interleukin-35 Signalling (Mus musculus)
Interleukin-35 Signalling (Rattus norvegicus)
Interleukin-35 Signalling (Sus scrofa)
Interleukin-35 Signalling (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000314
,
BIOMD0000000313
,
BIOMD0000000477
Authored
Jupe, S (2009-11-25)
Reviewed
Tanaka, M (2015-11-09)
Narazaki, M (2015-11-09)
Created
Varusai, TM (2017-04-10)
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