NKX3-2 binds RUNX2 gene promoter

Stable Identifier
R-HSA-8985293
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Based on studies in mice, the homeobox protein NKX3-2 (BAPX1), required for embryonic development of the axial skeleton (Tribioli and Lufkin 1999), binds the distal (P1) promoter of the RUNX2 gene (Lengner et al. 2005). NKX3-2 binding sites are conserved in the human RUNX2 promoter.
Literature References
PubMed ID Title Journal Year
10572046 The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen

Tribioli, C, Lufkin, T

Development 1999
15703179 Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation

van Wijnen, AJ, Lengner, CJ, Lian, JB, Stein, JL, Stein, GS, Lepper, C, Hassan, MQ, Serra, RW

J. Biol. Chem. 2005
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