SLIT2:ROBO1 increases RHOA activity

Stable Identifier
R-HSA-8985586
Type
Pathway
Species
Homo sapiens
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SLIT2:ROBO1 increases RHOA activity
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ROBO1 receptor, activated by SLIT2, binds to MYO9B and inhibits its RHOA GAP activity. SLIT2-ROBO1 signaling thus results in increased RHOA activity, which is thought to negatively regulate invasiveness of lung cancer cells (Kong et al. 2015). ROCK-mediated signaling and phosphorylation of the myosin regulatory light chain (MLRC) downstream of activated RHOA is needed for SLIT-mediated axon pathfinding in cranial motor neurons (Murray et al. 2010).

Literature References
PubMed ID Title Journal Year
26529257 Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression

Kong, R, Yi, F, Wen, P, Liu, J, Chen, X, Ren, J, Li, X, Shang, Y, Nie, Y, Wu, K, Fan, D, Zhu, L, Feng, W, Wu, JY

J. Clin. Invest. 2015
Participants
Events
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Orthologous Events
SLIT2:ROBO1 increases RHOA activity (Bos taurus)
SLIT2:ROBO1 increases RHOA activity (Canis familiaris)
SLIT2:ROBO1 increases RHOA activity (Danio rerio)
SLIT2:ROBO1 increases RHOA activity (Gallus gallus)
SLIT2:ROBO1 increases RHOA activity (Mus musculus)
SLIT2:ROBO1 increases RHOA activity (Rattus norvegicus)
SLIT2:ROBO1 increases RHOA activity (Sus scrofa)
SLIT2:ROBO1 increases RHOA activity (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2017-06-26)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-04-18)