Reactome | SLIT2:ROBO1 increases RHOA activity

SLIT2:ROBO1 increases RHOA activity

Stable Identifier

R-HSA-8985586

Type

Pathway

Species

Homo sapiens

Locations in the PathwayBrowser

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Summation

ROBO1 receptor, activated by SLIT2, binds to MYO9B and inhibits its RHOA GAP activity. SLIT2-ROBO1 signaling thus results in increased RHOA activity, which is thought to negatively regulate invasiveness of lung cancer cells (Kong et al. 2015). ROCK-mediated signaling and phosphorylation of the myosin regulatory light chain (MLRC) downstream of activated RHOA is needed for SLIT-mediated axon pathfinding in cranial motor neurons (Murray et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
26529257	Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression Kong, R, Yi, F, Wen, P, Liu, J, Chen, X, Ren, J, Li, X, Shang, Y, Nie, Y, Wu, K, Fan, D, Zhu, L, Feng, W, Wu, JY	J. Clin. Invest.	2015