Reactome: A Curated Pathway Database

SLIT2:ROBO1 increases RHOA activity

Stable Identifier
R-HSA-8985586
Type
Pathway
Species
Homo sapiens
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Summation

ROBO1 receptor, activated by SLIT2, binds to MYO9B and inhibits its RHOA GAP activity. SLIT2-ROBO1 signaling thus results in increased RHOA activity, which is thought to negatively regulate invasiveness of lung cancer cells (Kong et al. 2015). ROCK-mediated signaling and phosphorylation of the myosin regulatory light chain (MLRC) downstream of activated RHOA is needed for SLIT-mediated axon pathfinding in cranial motor neurons (Murray et al. 2010).

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