COL1A1 gene expression is stimulated by RUNX2 and RB1

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R-HSA-8985644
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Reaction [omitted]
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Homo sapiens
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Based on mouse studies, binding of the RUNX2:RB1 complex to RUNX2-response elements in the promoter of the COL1A1 gene, encoding Collagen alpha-1(I) chain, stimulates COL1A1 transcription (Kern et al. 2001, Cola et al. 2010).

Literature References
PubMed ID Title Journal Year
20686481 Rb regulates fate choice and lineage commitment in vivo

Calo, E, Quintero-Estades, JA, Danielian, PS, Nedelcu, S, Berman, SD, Lees, JA

Nature 2010
11106645 Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes

Kern, B, Shen, J, Starbuck, M, Karsenty, G

J. Biol. Chem. 2001
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