Regulation of cortical dendrite branching

Stable Identifier
R-HSA-8985801
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Besides being involved in axon repulsion during neuronal system development, SLIT-ROBO signaling is also involved in dendrite branching. Based on studies in mice, SLIT1 triggers cortical dendrite branching by activating receptors ROBO1 and/or ROBO2. ROBO effector NCK2 is needed for SLIT1-mediated dendrite branching (Round and Sun 2011).

Literature References
PubMed ID Title Journal Year
21600986 The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology Mol. Cell. Neurosci. 2011
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