NCK2 binds to ROBO1,(ROBO2)

Stable Identifier
R-HSA-8985812
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Based on mouse experiments, SLIT1-activated ROBO receptors ROBO1 and/or ROBO2 bind to NCK2. The interaction involves three SH3 domains of NCK2 and the PxxP-rich region between CC2 and CC3 motifs in the cytoplasmic domain of ROBO. While NCK1 can also associate with ROBO receptors, only NCK2 is implicated in SLIT1-induced cortical dendrite branching (Round and Sun 2011).

Literature References
PubMed ID Title Journal Year
21600986 The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology

Round, JE, Sun, H

Mol. Cell. Neurosci. 2011
Participants
Participant Of
Inferred From
Authored
Reviewed
Created