Interleukin-9 signaling

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Interleukin 9 (IL9) binds interleukin 9 (IL9R) and (IL2RG) to release IL9 signaling downstream cascade. IL9R forms supramolecular clusters with Interleukin-2 receptors and MHC molecules in lipid rafts of human T lymphoma cells IL2RG is essential for IL9 dependent growth signal transduction (Kimura et al. 1995). IL9R (glycoprotein of 64 kDa) has saturable and specific binding sites with a Kd of 100 pM (Renauld et al. 1992). The activated IL9R complex employs the Tyrosine-protein kinase (JAK1) and Tyrosine-protein JAK3 (JAK3) for subsequent activation of the Signal transducer and activator transcription (STAT) factors STAT1, STAT3 and STAT5. The activated STATs form STAT5 dimers and STAT1:STAT3 heterodimers (Neurath & Finotto 2016, Li & Rostami 2010).

Literature References
PubMed ID Title Journal Year
26976761 IL-9 signaling as key driver of chronic inflammation in mucosal immunity Cytokine Growth Factor Rev. 2016
20020328 IL-9: basic biology, signaling pathways in CD4+ T cells and implications for autoimmunity J Neuroimmune Pharmacol 2010
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Event Information
Orthologous Events