Reactome | p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus

p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus

Stable Identifier

R-HSA-8985981

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus

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The Signal transducer and activator of transcription 1-alpha/beta (STAT1) -Signal transducer and activator of transcription 3 (STAT3) complex translocates from the cytosol to the nucleus. Interleukin-9 (IL9) stimulation induces STAT3 nuclear translocation and binding in vivo to the Eotaxin (CCL11) promoter (Yamasaki et al. 2010, Gounni et al. 2004). Interleukin-9 (IL9) stimulation induces mucin5AC, junB and c-myc transcription (Longphre et al. 1999, Kang et al, 1995).

This is a black box event because this evidence shows STAT3 translocation, but not translocation of a STAT1:STAT3 dimer.

Literature References

PubMed ID	Title	Journal	Year
10562299	Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells Basbaum, C, Wenzel, S, Li, D, Bice, DE, Drori, E, Longphre, M, Redman, T, Gallup, M, Ordoñez, CL, Fahy, JV	J. Clin. Invest.	1999
7775604	Activation of junB and c-myc primary response genes by interleukin 9 in a human factor-dependent cell line Kang, LY, Yang, YC	J. Cell. Physiol.	1995
20169197	IL-9 induces CCL11 expression via STAT3 signalling in human airway smooth muscle cells Koussih, L, Yamasaki, A, Halayko, AJ, Saleh, A, Muro, S, Gounni, AS	PLoS ONE	2010