USP33 deubiquitinates ROBO1

Stable Identifier
R-HSA-8986083
Type
Reaction [transition]
Species
Homo sapiens
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The ubiquitin protease USP33 deubiquitinates ROBO1, thus stabilizing it and increasing the concentration of ROBO1 at the plasma membrane (Yuasa-Kawada et al. 2009, Huang et al. 2015). USP33 is frequently downregulated in colorectal cancer, which is associated with lymph node metastasis and poor survival (Huang et al. 2015). USP33 is required for SLIT-ROBO1-mediated inhibition of breast cancer cell migration (Yuasa-Kawada et al. 2009). Ubiquitin ligases that ubiquitinate ROBO1 are not known.

Literature References
PubMed ID Title Journal Year
25242263 USP33 mediates Slit-Robo signaling in inhibiting colorectal cancer cell migration

Huang, Z, Wen, P, Kong, R, Cheng, H, Zhang, B, Quan, C, Bian, Z, Chen, M, Zhang, Z, Chen, X, Du, X, Liu, J, Zhu, L, Fushimi, K, Hua, D, Wu, JY

Int. J. Cancer 2015
19706539 Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration

Yuasa-Kawada, J, Kinoshita-Kawada, M, Rao, Y, Wu, JY

Proc. Natl. Acad. Sci. U.S.A. 2009
Participants
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Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of USP33 [cytosol]
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Activity
Orthologous Events
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