Reactome | HSPD1(1-26) [mitochondrial matrix]

HSPD1(1-26) [mitochondrial matrix]

Stable Identifier

R-HSA-8986171

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

HSPD1 transit peptide, 60 kDa heat shock protein, mitochondrial ecNumber3.6.4.9/ecNumber, CH60_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P10809 HSPD1

Gene Names

HSPD1, HSP60

Chain

transit peptide:1-26, chain:27-573

Reference Genes

BioGPS Gene:3329 HSPD1

COSMIC (genes):HSPD1 HSPD1

CTD Gene:3329 HSPD1

dbSNP Gene:3329 HSPD1

ENSEMBL:ENSG00000144381 HSPD1

HGNC:5261 HSPD1

KEGG Gene (Homo sapiens):3329 HSPD1

Monarch:3329 HSPD1

NCBI Gene:3329 HSPD1

OMIM:118190 HSPD1

UCSC:P10809 HSPD1

Reference Transcript

Other Identifiers

0002370647

0007050358

11737053_s_at

11745851_x_at

11746986_x_at

11753017_s_at

11753018_x_at

11757531_x_at

1523

16906962

200806_s_at

200807_s_at

243372_at

2593738

2593739

2593740

2593741

2593742

2593743

2593744

2593746

2593747

2593748

2593749

2593753

2593754

2593756

2593758

2593760

2593766

2593767

2593769

2593773

2593775

2669035

2775

2804031

2804032

2804035

2804036

2916228

2931975

3329

3403532

3417063

3442921

37720_at

3927935

4PJ1

50025

72816

8058052

A0A024R3X4

A_32_P25273

A_32_P76091

AAA36022

AAA60127

AAH02676

AAH03030

AAH67082

AAH73746

ABB01006

AC010746

AC020550

AC114809

ADO22410

AJ250915

AK301276

AK312240

ALQ33597

BAG35173

BAH13448

BC002676

BC003030

BC067082

BC073746

C9J0S9

C9JCQ4

C9JL19

C9JL25

CAB002775

CAB072816

CAB75426

CCDS33357

CH471063

DQ217936

E7ESH4

E7EXB4

EAW70148

EAW70150

EAW70152

EAW70153

ENSG00000144381

ENSP00000340019

ENSP00000373620

ENST00000345042

ENST00000345042.6

ENST00000388968

ENST00000388968.7

EntrezGene:3329

EntrezGene:HSPD1

F8WBB1

g4504520_3p_a_at

GE55300

GO:0000166

GO:0001530

GO:0002039

GO:0002368

GO:0002376

GO:0002755

GO:0002842

GO:0003674

GO:0003677

GO:0003688

GO:0003697

GO:0003723

GO:0003725

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005739

GO:0005743

GO:0005759

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0005905

GO:0006259

GO:0006357

GO:0006457

GO:0006458

GO:0006605

GO:0006810

GO:0006919

GO:0006950

GO:0006986

GO:0007005

GO:0007155

GO:0007165

GO:0008035

GO:0008150

GO:0008219

GO:0008283

GO:0008289

GO:0008637

GO:0009058

GO:0009409

GO:0009986

GO:0015031

GO:0016020

GO:0016032

GO:0016853

GO:0016887

GO:0019899

GO:0022607

GO:0030135

GO:0030141

GO:0031410

GO:0031625

GO:0032727

GO:0032729

GO:0032733

GO:0032735

GO:0032755

GO:0032991

GO:0034185

GO:0034186

GO:0034641

GO:0042026

GO:0042100

GO:0042110

GO:0042113

GO:0043032

GO:0043065

GO:0043066

GO:0043167

GO:0043226

GO:0044403

GO:0045041

GO:0046696

GO:0048291

GO:0048856

GO:0050821

GO:0050870

GO:0051082

GO:0051087

GO:0051131

GO:0051604

GO:0051702

GO:0055085

GO:0065003

GO:0070062

GQ900893

HGNC:5261

HPA001523

HPA050025

Hs.259742.0.A1_3p_at

Hs.79037.0.A1_3p_a_at

HSPD1

HSPD1-201

HSPD1-202

ILMN_1766713

ILMN_1774410

ILMN_1784367

ILMN_2381397

IPR001844

IPR002423

IPR018370

IPR027409

IPR027410

IPR027413

KU178139

M22382

M22382_at

M34664

MIM:118190

MIM:605280

MIM:612233

NM_002156

NM_199440

NP_002147

NP_955472

PF00118

PH_hs_0028995

PH_hs_0040685

PR00298

UPI0000042366

Participant Of

hasCandidate

Mitochondrial targeting peptides (from matrix proteins) [mitochondrial matrix]

Other forms of this molecule

HSPD1 [mitochondrial matrix]

HSPD1 [mitochondrial inner membrane]

HSPD1(1-573) [cytosol]

HSPD1(1-573) [mitochondrial inner membrane]

HSPD1(1-573) [mitochondrial intermembrane space]

Inferred To

Homologues of HSPD1(1-26) [mitochondrial matrix] (Canis familiaris)

HSPD1(1-26) [mitochondrial matrix] (Canis familiaris)

HSPD1(1-26) [mitochondrial matrix] (Danio rerio)

HSPD1(1-26) [mitochondrial matrix] (Gallus gallus)

HSPD1(1-26) [mitochondrial matrix] (Mus musculus)

HSPD1(1-26) [mitochondrial matrix] (Rattus norvegicus)

HSPD1(1-26) [mitochondrial matrix] (Saccharomyces cerevisiae)

HSPD1(1-26) [mitochondrial matrix] (Schizosaccharomyces pombe)

HSPD1(1-26) [mitochondrial matrix] (Sus scrofa)

HSPD1(1-26) [mitochondrial matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_955472.1, NP_002147.2

OpenTargets

ENSG00000144381

GeneCards

P10809

PRO

P10809

Orphanet

16233

PDB

4PJ1

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BRK4 LZTS2			0.781	7
UniProt:O75069-4 TMCC2			0.718	6
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.718	6
UniProt:Q9NTG7 SIRT3	2	SIRT3 [nucleoplasm] (R-HSA-9622879) SIRT3(?-399) [mitochondrial matrix] (R-HSA-1605416)	0.669	3
UniProt:Q6PI48 DARS2	1	DARS2 [mitochondrial matrix] (R-HSA-379679)	0.669	3
UniProt:Q8N6K7 SAMD3			0.666	4
UniProt:Q9JJY3	1	SMPD3 [plasma membrane] (R-MMU-1606265)	0.591	3
UniProt:Q9HD33 MRPL47	1	MRPL47 [mitochondrial inner membrane] (R-HSA-5368180)	0.564	2
UniProt:O15382 BCAT2	1	PXLP-BCAT2 [mitochondrial matrix] (R-HSA-70703)	0.564	2
UniProt:Q9Y4C4 MFHA1			0.558	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:O76081 RGS20	1	RGS20 [plasma membrane] (R-HSA-921136)	0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q7Z3S9 NT2NA			0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:O76081-6 RGS20			0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:Q5T440 CAF17			0.527	2
UniProt:Q96CB9 NSUN4	1	NSUN4 [mitochondrial matrix] (R-HSA-6793068)	0.527	2
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.527	2
UniProt:Q9Y2Z4 YARS2	1	YARS2 [mitochondrial matrix] (R-HSA-379634)	0.527	2
UniProt:Q9Y6E7 SIRT4	1	SIRT4 [mitochondrial matrix] (R-HSA-5687775)	0.527	2
UniProt:Q15120 PDK3	1	PDK3(?-406) [mitochondrial matrix] (R-HSA-203940)	0.527	2
UniProt:Q9BPW8 NIPS1			0.527	2
UniProt:P49590 HARS2	1	HARS2 [mitochondrial matrix] (R-HSA-379581)	0.527	2
UniProt:Q9NR28 DIABLO	2	DIABLO [cytosol] (R-HSA-114298) DIABLO [mitochondrial intermembrane space] (R-HSA-64637)	0.527	5
UniProt:Q96I59 NARS2	1	NARS2 [mitochondrial matrix] (R-HSA-379585)	0.527	2
UniProt:Q16822 PCK2	1	PCK2 [mitochondrial matrix] (R-HSA-372815)	0.527	2
UniProt:A8MXV4 NUDT19	2	NUDT19 [peroxisomal matrix] (R-HSA-6809219) NUDT19 [cytosol] (R-HSA-9033098)	0.527	2
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.527	3
UniProt:O75323 NIPS2			0.527	2
UniProt:O75489 NDUFS3	1	NDUFS3 [mitochondrial matrix] (R-HSA-163927)	0.527	5
UniProt:P13073 COX4I1	1	COX4I1 [mitochondrial inner membrane] (R-HSA-164305)	0.527	2
UniProt:P24539 ATP5PB	1	ATP5F1 [mitochondrial inner membrane] (R-HSA-164537)	0.527	2
UniProt:Q9BZE1 MRPL37	1	MRPL37 [mitochondrial inner membrane] (R-HSA-5368240)	0.527	2
UniProt:Q4G176 ACSF3	1	ACSF3 [mitochondrial matrix] (R-HSA-5696011)	0.527	2
UniProt:Q9NP92 MRPS30	1	MRPS30 [mitochondrial inner membrane] (R-HSA-5368258)	0.527	2
UniProt:P38398 BRCA1	5	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) BRCA1 [nucleoplasm] (R-HSA-50949) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.508	2
UniProt:P16885 PLCG2	10	p-PLCG2 [plasma membrane] (R-HSA-114602) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [plasma membrane] (R-HSA-114601) PLCG2 [cytosol] (R-HSA-984806) PLCG2 [plasma membrane] (R-HSA-2023875) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) PLCG2 [cytosol] (R-HSA-1604645) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.488	2
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.488	2
UniProt:A8MQ03 CRTP1			0.488	2
UniProt:Q9H7S9 ZNF703	1	ZNF703 [nucleoplasm] (R-HSA-2454149)	0.462	4