Reactome | HSPD1(1-26) [mitochondrial matrix]

HSPD1(1-26) [mitochondrial matrix]

Stable Identifier

R-HSA-8986171

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

HSPD1 transit peptide, 60 kDa heat shock protein, mitochondrial ecNumber3.6.4.9/ecNumber, CH60_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P10809 HSPD1

Gene Names

HSPD1, HSP60

Chain

transit peptide:1-26, chain:27-573

Reference Genes

BioGPS Gene:3329 HSPD1

COSMIC (genes):HSPD1 HSPD1

CTD Gene:3329 HSPD1

dbSNP Gene:3329 HSPD1

ENSEMBL:ENSG00000144381 HSPD1

HGNC:5261 HSPD1

KEGG Gene (Homo sapiens):3329 HSPD1

Monarch:3329 HSPD1

NCBI Gene:3329 HSPD1

OMIM:118190 HSPD1

UCSC:P10809 HSPD1

Reference Transcript

Other Identifiers

0002370647

0007050358

11737053_s_at

11745851_x_at

11746986_x_at

11753017_s_at

11753018_x_at

11757531_x_at

16906962

200806_s_at

200807_s_at

243372_at

2593738

2593739

2593740

2593741

2593742

2593743

2593744

2593746

2593747

2593748

2593749

2593753

2593754

2593756

2593758

2593760

2593766

2593767

2593769

2593773

2593775

2669035

2804031

2804032

2804035

2804036

2916228

2931975

3329

3403532

3417063

3442921

37720_at

3927935

8058052

A_32_P25273

A_32_P76091

GE55300

GO:0000166

GO:0001530

GO:0001666

GO:0002020

GO:0002039

GO:0002368

GO:0002376

GO:0002755

GO:0002842

GO:0002931

GO:0003674

GO:0003677

GO:0003688

GO:0003697

GO:0003723

GO:0003725

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005739

GO:0005743

GO:0005759

GO:0005768

GO:0005769

GO:0005777

GO:0005782

GO:0005783

GO:0005791

GO:0005794

GO:0005829

GO:0005886

GO:0005905

GO:0006259

GO:0006357

GO:0006457

GO:0006458

GO:0006605

GO:0006810

GO:0006919

GO:0006950

GO:0006986

GO:0007005

GO:0007155

GO:0007165

GO:0007267

GO:0008035

GO:0008150

GO:0008219

GO:0008283

GO:0008289

GO:0008637

GO:0009058

GO:0009408

GO:0009409

GO:0009986

GO:0010033

GO:0014070

GO:0014823

GO:0015031

GO:0016020

GO:0016032

GO:0016853

GO:0016887

GO:0019899

GO:0022607

GO:0030061

GO:0030135

GO:0030141

GO:0031410

GO:0031625

GO:0032496

GO:0032727

GO:0032729

GO:0032733

GO:0032735

GO:0032755

GO:0032991

GO:0033198

GO:0034185

GO:0034186

GO:0034514

GO:0034605

GO:0034641

GO:0042026

GO:0042100

GO:0042110

GO:0042113

GO:0042220

GO:0042493

GO:0042542

GO:0042588

GO:0043032

GO:0043065

GO:0043066

GO:0043167

GO:0043226

GO:0043231

GO:0043524

GO:0043559

GO:0043627

GO:0044403

GO:0044877

GO:0045041

GO:0045121

GO:0046696

GO:0048291

GO:0048856

GO:0050729

GO:0050821

GO:0050870

GO:0051082

GO:0051087

GO:0051131

GO:0051384

GO:0051604

GO:0051702

GO:0055085

GO:0065003

GO:0070062

GO:0071866

GO:0098761

GO:0140030

GO:1903427

GO:1904469

Hs.259742.0.A1_3p_at

Hs.79037.0.A1_3p_a_at

ILMN_1766713

ILMN_1774410

ILMN_1784367

ILMN_2381397

M22382_at

PH_hs_0028995

PH_hs_0040685

g4504520_3p_a_at

Participant Of

hasCandidate

Mitochondrial targeting peptides (from matrix proteins) [mitochondrial matrix]

Other forms of this molecule

HSPD1 [mitochondrial matrix]

HSPD1 [mitochondrial inner membrane]

HSPD1(1-573) [cytosol]

HSPD1(1-573) [mitochondrial inner membrane]

HSPD1(1-573) [mitochondrial intermembrane space]

Inferred To

HSPD1 [mitochondrial matrix] (Gallus gallus)

Hspd1 [mitochondrial matrix] (Mus musculus)

Hspd1 [mitochondrial matrix] (Rattus norvegicus)

hspd1 [mitochondrial matrix] (Danio rerio)

hspd1 [mitochondrial matrix] (Xenopus tropicalis)

HSPD1(1-26) [mitochondrial matrix] (Canis familiaris)

hsp60 [mitochondrial matrix] (Schizosaccharomyces pombe)

HSP60 [mitochondrial matrix] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_955472.1, NP_002147.2

OpenTargets

ENSG00000144381

HPA

ENSG00000144381-HSPD1

GeneCards

P10809

Ensembl

ENST00000388968, ENSG00000144381, ENSP00000340019, ENSP00000373620, ENST00000345042

PRO

P10809

Orphanet

16233

PDB

4PJ1, 6HT7, 6MRD, 6MRC

Interactors (67)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BRK4 LZTS2			0.781	7
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.718	6
UniProt:Cerebral CLONE			0.718	6
UniProt:Q6PI48 DARS2	1	DARS2 [mitochondrial matrix] (R-HSA-379679)	0.669	3
UniProt:Q9NTG7 SIRT3	2	SIRT3 [nucleoplasm] (R-HSA-9622879) SIRT3(?-399) [mitochondrial matrix] (R-HSA-1605416)	0.669	3
UniProt:Q8N6K7 SAMD3			0.666	4
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [nucleoplasm] (R-HSA-450250) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.666	5
UniProt:Q9JJY3	1	Smpd3 [plasma membrane] (R-MMU-1606265)	0.591	3
UniProt:Q9NVI7 ATD3A			0.576	4
UniProt:O15382 BCAT2	1	PXLP-BCAT2 [mitochondrial matrix] (R-HSA-70703)	0.564	2
UniProt:Q9HD33 MRPL47	1	MRPL47 [mitochondrial inner membrane] (R-HSA-5368180)	0.564	2
UniProt:Q9Y4C4 MFHA1			0.558	3
UniProt:Q9UBU7 DBF4	1	DBF4 [nucleoplasm] (R-HSA-68387)	0.556	3
UniProt:P22607 FGFR3	40	FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 795fs139 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419) p-6Y-FGFR3 S371C [plasma membrane] (R-HSA-2011886) p-6Y-FGFR3 G370C [plasma membrane] (R-HSA-2011883) p-6Y-FGFR3 Y373C [plasma membrane] (R-HSA-2011889) p-6Y-FGFR3 795fs139 [plasma membrane] (R-HSA-2038360) p-6Y-FGFR3 R248C [plasma membrane] (R-HSA-2011884) pY-FGFR3 [plasma membrane] (R-HSA-2038368) p-6Y-FGFR3 K650Q [plasma membrane] (R-HSA-2032962) p-6Y-FGFR3 K650N [plasma membrane] (R-HSA-2032961) p-6Y-FGFR3 K650E [plasma membrane] (R-HSA-2032952) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-4Y FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853147) p-4Y FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853155) p-4Y FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853145) p-4Y FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853129) p-4Y FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853151) p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853128) FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127)	0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
IntAct:EBI-25861394 CCSB			0.556	3
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.556	3
UniProt:P12036 NFH			0.556	3
UniProt:O76081-6 RGS20			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q9UMX3 BOK			0.556	3
UniProt:Q6ZQX7-4 Q6ZQX74			0.556	3
UniProt:A0A024RCP2 A0A024RCP2			0.556	3
UniProt:Q6NXG1 ESRP1	3	ESRP1-RAF1 fusion [cytosol] (R-HSA-6802312) p-ESRP1-RAF1 fusion [cytosol] (R-HSA-6802523) ESRP1 [nucleoplasm] (R-HSA-6803472)	0.556	3
UniProt:P01112 HRAS	23	HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912)	0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:O76081 RGS20	1	RGS20 [plasma membrane] (R-HSA-921136)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q9UBQ0-2 VPS29			0.556	3
UniProt:P61158 ACTR3	1	ACTR3 [cytosol] (R-HSA-200811)	0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:A0A0C4DFM3 A0A0C4DFM3			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q99944 EGFL8			0.556	3
UniProt:Q99504 EYA3	2	p-EYA3 [nucleoplasm] (R-HSA-5683979) EYA3 [nucleoplasm] (R-HSA-5683622)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q7Z3S9 NT2NA			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q14957 GRIN2C	3	p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [plasma membrane] (R-HSA-419560) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	6
UniProt:Q96CB9 NSUN4	1	NSUN4 [mitochondrial matrix] (R-HSA-6793068)	0.527	2
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.527	2
UniProt:Q9Y2Z4 YARS2	1	YARS2 [mitochondrial matrix] (R-HSA-379634)	0.527	2
UniProt:Q9Y6E7 SIRT4	1	SIRT4 [mitochondrial matrix] (R-HSA-5687775)	0.527	2
UniProt:Q15120 PDK3	1	PDK3(?-406) [mitochondrial matrix] (R-HSA-203940)	0.527	2
UniProt:Q5T9A4 ATAD3B	3	ATAD3B [plasma membrane] (R-HSA-6806518) ATAD3B [secretory granule membrane] (R-HSA-6801313) ATAD3B [ficolin-1-rich granule membrane] (R-HSA-6801277)	0.527	2
UniProt:P24539 ATP5PB	1	ATP5F1 [mitochondrial inner membrane] (R-HSA-164537)	0.527	2
UniProt:Q9BZE1 MRPL37	1	MRPL37 [mitochondrial inner membrane] (R-HSA-5368240)	0.527	2
UniProt:Q9NP92 MRPS30	1	MRPS30 [mitochondrial inner membrane] (R-HSA-5368258)	0.527	2
UniProt:Q5T440 CAF17			0.527	2
UniProt:Q9BPW8 NIPS1			0.527	2
UniProt:Q16822 PCK2	1	PCK2 [mitochondrial matrix] (R-HSA-372815)	0.527	2
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.527	3
UniProt:O75323 NIPS2			0.527	2
UniProt:P13073 COX4I1	1	COX4I1 [mitochondrial inner membrane] (R-HSA-164305)	0.527	2
UniProt:Q9NR28 DIABLO	2	DIABLO [mitochondrial intermembrane space] (R-HSA-64637) DIABLO [cytosol] (R-HSA-114298)	0.527	5
UniProt:Q96I59 NARS2	1	NARS2 [mitochondrial matrix] (R-HSA-379585)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	10
UniProt:A8MXV4 NUDT19	2	NUDT19 [peroxisomal matrix] (R-HSA-6809219) NUDT19 [cytosol] (R-HSA-9033098)	0.527	2
UniProt:Q4G176 ACSF3	1	ACSF3 [mitochondrial matrix] (R-HSA-5696011)	0.527	2
UniProt:O75489 NDUFS3	1	NDUFS3 [mitochondrial matrix] (R-HSA-163927)	0.527	5
UniProt:P49590 HARS2	1	HARS2 [mitochondrial matrix] (R-HSA-379581)	0.527	2
UniProt:P38398 BRCA1	27	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) BRCA1 C64R [nucleoplasm] (R-HSA-9700907) BRCA1 C61G [nucleoplasm] (R-HSA-9700890) BRCA1 C39Y [nucleoplasm] (R-HSA-9700938) BRCA1 H41R [nucleoplasm] (R-HSA-9700921) BRCA1 C24R [nucleoplasm] (R-HSA-9663198) BRCA1 H41A [nucleoplasm] (R-HSA-9700927) BRCA1 M18T [nucleoplasm] (R-HSA-9700911) BRCA1 C47G [nucleoplasm] (R-HSA-9700941) BRCA1 C64G [nucleoplasm] (R-HSA-9700899) BRCA1 C44F [nucleoplasm] (R-HSA-9700944) BRCA1 T37R [nucleoplasm] (R-HSA-9700934) BRCA1 C27A [nucleoplasm] (R-HSA-9700916) BRCA1 H41Q [nucleoplasm] (R-HSA-9700923) BRCA1 Q12Tfs5 [nucleoplasm] (R-HSA-9700953) BRCA1 E23Afs18 [nucleoplasm] (R-HSA-9700959) BRCA1 C61Y [nucleoplasm] (R-HSA-9700894) BRCA1 C24F [nucleoplasm] (R-HSA-9663206) BRCA1 E23Rfs18 [nucleoplasm] (R-HSA-9700960) BRCA1 E23Vfs17 [nucleoplasm] (R-HSA-9700967) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707298) BRCA1 [nucleoplasm] (R-HSA-50949) K6PolyUb-BRCA1 [nucleoplasm] (R-HSA-9701022) K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707290) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.508	2
UniProt:P16885 PLCG2	10	PLCG2 [cytosol] (R-HSA-984806) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) PLCG2 [plasma membrane] (R-HSA-2023875) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) PLCG2 [cytosol] (R-HSA-1604645) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.488	2
UniProt:Q9H7S9 ZNF703	1	ZNF703 [nucleoplasm] (R-HSA-2454149)	0.462	4

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