Reactome | IL26:IL20RA:JAK1 binds IL10RB:TYK2

IL26:IL20RA:JAK1 binds IL10RB:TYK2

Stable Identifier

R-HSA-8986480

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region, cytosol

Synonyms

IL10RB:TYK2 receptor complex binds IL26:IL20RA:JAK1 receptor complex, IL26:IL20RA complex binds IL10RB

ReviewStatus

5/5

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The interaction of Interleukin-26 (IL26) with Interleukin-20 receptor subunit alpha (IL20RA) induces conformational changes that allow it to bind Interleukin-10 receptor subunit beta (IL10RB) (Yoon et al. 2006, 2010), which is pre associated with Non-receptor tyrosine-protein kinase TYK2 (TYK2) (another citation).

Literature References

PubMed ID	Title	Journal	Year
16982608	Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex Logsdon, NJ, Yoon, SI, Sheikh, F, Donnelly, RP, Walter, MR	J. Biol. Chem.	2006
14764663	Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2 Baurin, VV, Lewis-Antes, A, Shah, NK, Dumoutier, L, Zdanov, A, Anantha, S, Smirnov, SV, Sheikh, F, Renauld, JC, Dickensheets, H, Donnelly, RP, Kotenko, SV	J. Immunol.	2004
20462497	Structure and mechanism of receptor sharing by the IL-10R2 common chain Yoon, SI, Radaeva, S, Jones, BC, Gao, B, Logsdon, NJ, Halloran, BA, Deshpande, A, Harris, BD, Walter, MR	Structure	2010