MECP2 binds MET gene promoter

Stable Identifier
R-HSA-8986943
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MECP2 binds MET gene promoter
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MECP2 binds the promoter of the MET gene, encoding receptor tyrosine kinase MET. The MECP2 binding site in the MET promoter contains the SNV sequence whose rs1858830 C 'low activity' allele is associated with an increased risk for autism spectrum disorders (ASD) (Plummer et al. 2013).
Literature References
PubMed ID Title Journal Year
24150225 Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome

Bergman, MY, Evgrafov, OV, Plummer, JT, Aldinger, KA, Friez, M, Haiman, CA, Levitt, P

Transl Psychiatry 2013
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Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-05-05)
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