Reactome: A Curated Pathway Database

IL24 binds IL20RA:JAK1:IL20RB

Stable Identifier
R-HSA-8986972
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Synonyms
IL24 binds to IL20RA:JAK1:IL20RB receptor complex, IL20RA:IL20RB binds IL24
Locations in the PathwayBrowser
Summation

Interleukin-24 (IL24) binds a receptor complex containing Interleukin-20 Receptor subunit alpha (IL20RA) associated with Tyrosine-protein kinase JAK1 (JAK1) (Andoh et al. 2009, Logsdon et al. 2012) and Interleukin-20 receptor subunit beta (IL20RB) (Parrish Novak et al.1998). Furthermore IL24 can also bind Interleukin-22 receptor subunit alpha-1 (IL22RA1) and IL20RB (Wang et al. 2002) to form a ligand receptor complex.
As it is not clear whether the receptor complex can form in the absence of ligand, formation of the receptor dimer is represented here as an uncertain event.

Literature References
Participants
Participant Of
Orthologous Events