IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2

Stable Identifier
R-HSA-8986994
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
JAK1 and TYK2 are phosphorylated by IL26:IL20RA:JAK1:IL10RB:TYK2 receptor complex, JAK1 and TYK2 are phosphorylated after il26 il26 receptor interaction
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Tyrosine-protein kinase JAK1 (JAK1) and Non-receptor tyrosine-protein kinase TYK2 (TYK2) are believed to be phosphorylated after Interleukin-26 (IL26) ligand/receptor interaction. The Interleukin-10 receptor subunit beta (IL10RB) component of the IL26 receptor is also a component of the IL10 receptor, where it associates with TYK2 (Finbloom & Winestock 1995). The Interleukin-20 receptor subunit alpha (IL20RA) component of the IL26 receptor, like the Interleukin-10 receptor subunit alpha (IL10RA) subunit of the IL10 receptor, is a type II cytokine receptor, suggested by homology with IL10RA to be capable of binding JAK1 (Ferrao et al. 2016). Structural models of the IL10 receptor suggest that the space between the two receptor subunits is occupied by JAK1 and TYK2 (Yoon et al. 2006, 2010). Taken together, these observations suggest that IL26 receptor signaling involves JAK1 and TYK2 activation.

Literature References
PubMed ID Title Journal Year
16982608 Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex

Yoon, SI, Logsdon, NJ, Sheikh, F, Donnelly, RP, Walter, MR

J. Biol. Chem. 2006
7543512 IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes

Finbloom, DS, Winestock, KD

J. Immunol. 1995
14764663 Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2

Sheikh, F, Baurin, VV, Lewis-Antes, A, Shah, NK, Smirnov, SV, Anantha, S, Dickensheets, H, Dumoutier, L, Renauld, JC, Zdanov, A, Donnelly, RP, Kotenko, SV

J. Immunol. 2004
20462497 Structure and mechanism of receptor sharing by the IL-10R2 common chain

Yoon, SI, Jones, BC, Logsdon, NJ, Harris, BD, Deshpande, A, Radaeva, S, Halloran, BA, Gao, B, Walter, MR

Structure 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL26:IL20RA:JAK1:IL10RB:TYK2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created