Reactome | p-STAT1 dimerizes

p-STAT1 dimerizes

Stable Identifier

R-HSA-8987007

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-STAT1 dimerizes after IL24 stimulus, p-STAT1 dimerizes after receptor activation

ReviewStatus

5/5

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Signal transducer and activator of transcription 1alpha/beta (STAT1) is believed to dimerize after it dissociates from the Interleukin-24 (IL24) receptor complex. This is a black box event because dimerization is inferred from STAT1 dimerization in response to Interferon gamma (IFNG) (Wehinger et al. 1996) and the observed translocation of STAT1 to the nucleus in response to IL24 (Parrish-Novak et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
12351624	Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions Parrish-Novak, J, Xu, W, Brender, T, Yao, L, Jones, C, West, J, Brandt, C, Jelinek, L, Madden, K, McKernan, PA, Foster, DC, Jaspers, S, Chandrasekher, YA	J Biol Chem	2002
8830676	IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes Wehinger, J, Gouilleux, F, Groner, B, Finke, J, Mertelsmann, R, Weber-Nordt, RM	FEBS Lett.	1996