IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3

Stable Identifier
R-HSA-8987014
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
STAT3 binds to IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 activated receptor complex, STAT3 binds IL22 activated receptor complex
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Signal transducer and activator of transcription 3 (STAT3) is believed to bind the Interleukin-22 (IL22) receptor complex, which consists of IL22, phosphorylated Interleukin-22 receptor subunit alpha-1 (IL22RA1), phosphorylated Tyrosine-protein kinase JAK1 (JAK1), Interleukin-10 receptor subunit beta (IL10RB), phosphorylated Non-receptor tyrosine-protein kinase TYK2 (TYK2) and Tyrosine-protein phosphatase non-receptor type 11 (PTPN11 or SHP2) (Meng et al. 2010, Sestito et al. 2011). STAT3 has been reported to pre-associate with IL22RA in the absence of phosphorylated receptor tyrosines (Dumoutier et al. 2009).
This is a black box event because STAT3 binding is represented here as a post-receptor phosphorylation event, inferred from the consensus on interleukin receptor JAK-STAT signaling (Li et al. 2008, Santos et al. 2011).

Literature References
PubMed ID Title Journal Year
21098725 STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation

Sestito, R, Madonna, S, Scarponi, C, Cianfarani, F, Failla, CM, Cavani, A, Girolomoni, G, Albanesi, C

FASEB J. 2011
Participants
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