IL20 binds IL20RA:JAK1:IL20RB

Stable Identifier
R-HSA-8987015
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Synonyms
IL20 binds IL20RA:JAK1:IL20RB receptor complex
Locations in the PathwayBrowser
Summation

Interleukin-20 (IL20) binds a heterodimeric receptor complex that consists of Interleukin-20 receptor subunit alpha (IL20RA), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB) (Blumberg et al. 2001, Parrish-Novak et al. 2002, Logsdon et al. 2012, Rutz et al. 2014). Interleukin-20 receptor A (IL20RA) and Interleukin-20 receptor B (IL20RB) form a receptor complex for Interleukin-20 (IL20), Interleukin-19 (IL19) and Interleukin-24 (IL24) (Blumberg et al. 2001, Parrish-Novak et al. 2002, Logsdon et al. 2012, Rutz et al. 2014). IL20 can also bind a receptor complex that consists of Interleukin-22 receptor subunit alpha-1 (IL22RA1) and IL20RB (Kolumam et al. 2017). As it is not clear whether the dimeric receptor can form in the absence of ligand, formation of the receptor dimer is represented here as an uncertain black box event.

Literature References
PubMed ID Title Journal Year
11163236 Interleukin 20: discovery, receptor identification, and role in epidermal function

Blumberg, H, Conklin, D, Xu, WF, Grossmann, A, Brender, T, Carollo, S, Eagan, M, Foster, D, Haldeman, BA, Hammond, A, Haugen, H, Jelinek, L, Kelly, JD, Madden, K, Maurer, MF, Parrish-Novak, J, Prunkard, D, Sexson, S, Sprecher, C, Waggie, K, West, J, Whitmore, TE, Yao, L, Kuechle, MK, Dale, BA, Chandrasekher, YA

Cell 2001
22802649 Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines

Logsdon, NJ, Deshpande, A, Harris, BD, Rajashankar, KR, Walter, MR

Proc. Natl. Acad. Sci. U.S.A. 2012
12351624 Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions

Parrish-Novak, J, Xu, W, Brender, T, Yao, L, Jones, C, West, J, Brandt, C, Jelinek, L, Madden, K, McKernan, PA, Foster, DC, Jaspers, S, Chandrasekher, YA

J Biol Chem 2002
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