p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5

Stable Identifier
R-HSA-8987033
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
p-STAT1 dissociates from IFNL1:p-Y343-Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1 activated receptor complex, phosphorylated STAT1 dissociates from IL29-IL29 receptor complex
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Phosphorylated Signal transducer and activator of transcription 1 alpha/beta (STAT1), Phosphorylated Signal transducer and activator of transcription 2 (STAT2) , Phosphorylated Signal transducer and activator of transcription 3 (STAT3) , Phosphorylated Signal transducer and activator of transcription 4 (STAT4) and Phosphorylated Signal transducer and activator of transcription 5 (STAT5) are believed to dissociate from the receptor complex (Dumoutier et al. 2004, Novak et al. 2008). This is a black-box event because dissociation is inferred from other interleukin signaling cascades such as Interleukin-10 (Niemand et al. 2003, Braum et al. 2013, Xiong et al. 2014, Sheikh et al. 2006, You et al. 2013) where dissociation occurs before STAT dimerization and translocation to the nucleus.

Literature References
PubMed ID Title Journal Year
18830264 A role for IFN-lambda1 in multiple myeloma B cell growth

Novak, AJ, Grote, DM, Ziesmer, SC, Rajkumar, V, Doyle, SE, Ansell, SM

Leukemia 2008
Participants
Participant Of
Orthologous Events
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Created